Financiado en parte por U.S. Highbush Blueberry Council
Whole Blueberry and Isolated Polyphenol-Rich Fractions Modulate Specific Gut Microbes in an In Vitro Colon Model and in a Pilot Study in Human Consumers
Ntemiri A, Ghosh TS, Gheller ME, Tran TTT, Blum JE, Pellanda P, Vlckova K, Neto MC, Howell A, Thalacker-Mercer A, O'Toole PW
Nutrients · 46 citas
Etiquetas de revisión
Vínculos de autores con la industriaAlimentación controladaFinanciado por la industriaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo clínico controlado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- National Science Foundation
- Gobierno
- Food Institutional Research Measure
- Grupo de la industria
- U.S. Highbush Blueberry Council
- Gobierno
- Department of Agriculture, Food and the Marine, Ireland
- Gobierno
- Science Foundation Ireland
- Gobierno
- National Science Foundation Graduate Research Fellowship Program
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Science Foundation Graduate Research Fellowship Program (DGE-1650441); Science Foundation Ireland (12/RC/); Science Foundation Ireland (12/RC/2273_P2); National Science Foundation (1650441); National Science Foundation (DGE-165-0441)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-09-12 · Nutrients · vol. 12 · número 9 · pág. 2800
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 71 citas · más que el 90% de estudios similares · 2.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 107 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Gut microbiota and health · Nutritional Studies and Diet · Phytochemicals and Antioxidant Activities
- Palabras clave
- Polyphenol, Bioconversion, Food science, Gut flora, Feces, Microbiome, Biology, Bacteria, Proanthocyanidin, Sugar, Biochemistry, Antioxidant, Chemistry, Microbiology, Fermentation
- MeSH
- colon, feces, humans, anthocyanins, flavonols, glycosides, antioxidants, pilot projects, fermentation, oxidative stress, models, anatomic, adult, aged, female, young adult, polyphenols, healthy volunteers, gastrointestinal microbiome, blueberry plants
11 autores
- Alexandra Ntemiri🇮🇪University College Cork; APC Microbiome Institute
- Tarini Shankar Ghosh🇮🇪University College Cork; APC Microbiome Institute
- Molly E. Gheller🇺🇸Cornell University
- Tam T. T. Tran🇮🇪University College Cork; APC Microbiome Institute
- Jamie Blum🇺🇸Cornell University
- Paola Pellanda🇮🇪University College Cork; APC Microbiome Institute
- Klára Vlčková🇮🇪University College Cork; APC Microbiome Institute
- Marta C. Neto🇮🇪University College Cork; APC Microbiome Institute
- Amy B. Howell🇺🇸Rutgers, The State University of New Jersey; Cranberry Institute
- Anna Elizabeth Thalacker‐Mercer🇺🇸Cornell University; University of Alabama at Birmingham
- Paul William O’Toole🇮🇪 · autor de correspondenciaUniversity College Cork; APC Microbiome Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Blueberry (BB) consumption is linked to improved health. The bioconversion of the polyphenolic content of BB by fermentative bacteria in the large intestine may be a necessary step for the health benefits attributed to BB consumption. The identification of specific gut microbiota taxa that respond to BB consumption and that mediate the bioconversion of consumed polyphenolic compounds into bioactive forms is required to improve our understanding of how polyphenols impact human health. We tested the ability of polyphenol-rich fractions purified from whole BB-namely, anthocyanins/flavonol glycosides (ANTH/FLAV), proanthocyanidins (PACs), the sugar/acid fraction (S/A), and total polyphenols (TPP)-to modulate the fecal microbiota composition of healthy adults in an in vitro colon system. In a parallel pilot study, we tested the effect of consuming 38 g of freeze-dried BB powder per day for 6 weeks on the fecal microbiota of 17 women in two age groups (i.e., young and older). The BB ingredients had a distinct effect on the fecal microbiota composition in the artificial colon model. The ANTH/FLAV and PAC fractions were more effective in promoting microbiome alpha diversity compared to S/A and TPP, and these effects were attributed to differentially responsive taxa. Dietary enrichment with BB resulted in a moderate increase in the diversity of the microbiota of the older subjects but not in younger subjects, and certain health-relevant taxa were significantly associated with BB consumption. Alterations in the abundance of some gut bacteria correlated not only with BB consumption but also with increased antioxidant activity in blood. Collectively, these pilot data support the notion that BB consumption is associated with gut microbiota changes and health benefits.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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