Evaluation of Salivary Matrix Metalloproteinase (MMP-8) in Periodontal Patients Undergoing Non-Surgical Periodontal Therapy and Mouthwash Based on Ozonated Olive Oil: A Randomized Clinical Trial
Nardi GM, Cesarano F, Papa G, Chiavistelli L, Ardan R, Jedlinski M, Mazur M, Grassi R, Grassi FR
International journal of environmental research and public health · 25 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-09-11 · Int J Environ Res Public Health · vol. 17 · número 18 · pág. 6619
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 43 citas · más que el 97% de estudios similares · 5.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Oral microbiology and periodontitis research · Medical and Biological Ozone Research · Periodontal Regeneration and Treatments
- Palabras clave
- matrix metalloproteinase-8, periodontitis, non-surgical periodontal therapy, scaling and root planing, ozonated olive oil, mouthwash, ozone therapy, extracellular matrix metalloproteinases, plaque index, bleeding on probing, probing depth
- MeSH
- humans, mouthwashes, periodontal index, follow-up studies, root planing, matrix metalloproteinase 8, olive oil
9 autores
- Gianna Maria Nardi🇮🇹Sapienza University of Rome
- Francesca Cesarano🇮🇹Sapienza University of Rome
- Giulio Papa🇮🇹Sapienza University of Rome
- Lorella Chiavistelli🇮🇹Sapienza University of Rome
- Roman Ardan🇵🇱Koszalin University of Technology
- Maciej Jedliński🇵🇱Pomeranian Medical University
- Marta Mazur🇮🇹 · autor de correspondenciaSapienza University of Rome
- Roberta Grassi🇮🇹University of Sassari
- Felice Roberto Grassi🇮🇹University of Bari Aldo Moro
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Extracellular matrix metalloproteinases (MMPs) play a pivotal role in the damage to the periodontal tissue in patients with periodontitis. Scaling and root planning (SRP) attempt to control the plaque amount and consequentially reduce the bacterial load. Non-surgical periodontal treatment could be integrated with drug therapy and physiotherapy procedures such as ozone therapy. The aim of this study was to evaluate in a cohort of patients with a diagnosis of periodontitis: (1) the efficacy of non-surgical periodontal therapy assisted by the use of ozonated olive oil-based mouthwash on salivary metalloproteinase (MMP-8) and (2) the reduction of periodontal indices. Methods: Ninety-six subjects with a diagnosis of periodontitis were enrolled in this study and randomly assigned to the study group (SRP + mouthwash) or control group (SRP). The study duration was 3 months. Data on MMP-8, plaque index (PI), bleeding on probing (BoP) and probing pocket depth (PPD) were recorded at T0, T1 (14 days), T2 (1 month) and T3 (6 months). Group differences were assessed using Student's t-test for independent samples. Results: A significant improvement in PI, BoP, PPD and salivary MMP-8 levels was observed in both groups. An analysis of differences in relative changes of indices revealed the efficacy of ozonated olive oil in decreasing MMP-8 level. Simultaneously, it slowed the decrease of BoP index. Conclusions: Scaling and root plaining with the aid of ozonated olive oil mouthwash were found to be more effective on salivary MMP-8 reduction than scaling and root plaining alone.
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