Effects of intermittent fasting diets on plasma concentrations of inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials
Wang X, Yang Q, Liao Q, Li M, Zhang P, Santos HO, Kord-Varkaneh H, Abshirini M
Nutrition (Burbank, Los Angeles County, Calif.) · 73 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (81660149)
Según 1 financiador declarado.
Publicación
- Publicado
- 2020-08-12 · Nutrition · vol. 79-80 · pág. 110974
- Editorial
- Elsevier BV
- Citado
- 101 citas · más que el 91% de estudios similares · 2.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 65 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Nutritional Studies and Diet · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- intermittent fasting, hypocaloric diet, inflammatory markers, C-reactive protein, TNF-α, interleukin-6, obesity, overweight, inflammation, dietary intervention, treatment duration, weight loss, fasting-mimicking diet, ketogenic diet, low-carbohydrate diet, Mediterranean diet
- MeSH
- humans, inflammation, c-reactive protein, diet, fasting, dietary supplements, randomized controlled trials as topic, biomarkers
8 autores
- Xiaoli Wang🇨🇳 · autor de correspondenciaTongde Hospital of Zhejiang Province
- Qingqing Yang🇨🇳Tongde Hospital of Zhejiang Province
- Qiumei Liao🇨🇳Tongde Hospital of Zhejiang Province
- Mengdi Li🇨🇳Tongde Hospital of Zhejiang Province
- Pengyu Zhang🇨🇳Tongde Hospital of Zhejiang Province
- Heitor Oliveira Santos🇧🇷Universidade Federal de Uberlândia
- Hamed Kord‐Varkaneh🇮🇷Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Maryam Abshirini🇳🇿Massey University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Intermittent fasting (IF) and energy-restricted diets (ERDs) have emerged as dietary approaches to decrease inflammatory status; however, there are no consistent results regarding humans. To achieve a comprehensive conclusion, we aimed to conduct a meta-analysis of randomized control trials (RCTs) to evaluate the effects of IF or ERDs on plasma concentrations of inflammatory biomarkers. We systematically searched online medical databases including Web of Sciences, PubMed, SCOPUS, and Google Scholar up to June 2019. Evaluations of effect sizes were described employing in weighted mean difference and 95% confidence intervals from the random-effects model. Eighteen eligible RCTs were included in this meta-analysis. The pooled estimation from the random-effect model showed that IF regimens and ERDs significantly reduced C-reactive protein (CRP) concentrations (WMD: -0.024 mg/dL; 95% CI: -0.044 to -0.005, I2 = 7.0%). Additionally, IF regimens (WMD: -0.029; 95% CI: -0.058 to -0.000, I2 = 17.9%) were more effective in reducing CRP levels than ERDs (WMD: -0.001 mg/dL; 95% CI: -0.037 to 0.034, I2 = 0.0%). Moreover, based on the treatment duration and types of the studies' population, a greater reduction was observed in overweight and obese individuals (WMD: -0.03 mg/dL; 95% CI: -0.05 to 0.01, I2 = 42.1%), and in treatment duration ≥8 wk (WMD: -0.03 mg/dL; 95% CI: -0.05 to 0.01, I2 = 0.0%) as well. However, IF and ERDs did not significantly reduced tumor necrosis factor-α (WMD: -0.158 pg/mL; P = 0.549, I2 = 98.3) and interleukin-6 (IL-6) concentrations (WMD: -0.541 pg/mL; P = 0.080, I2 = 94.7%). This meta-analysis demonstrated that IF regimens and ERDs may reduce CRP concentrations, particularly in overweight and obese individuals and through a considerable length of intervention (≥2 mo). However, neither dietary model affected the concentrations of tumor necrosis factor-α or interleukin-6.
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