Walnut intake may increase circulating adiponectin and leptin levels but does not improve glycemic biomarkers: A systematic review and meta-analysis of randomized clinical trials
Yang L, Guo Z, Qi S, Fang T, Zhu H, Santos HO, Khani V, Wong CH, Qiu Z
Complementary therapies in medicine · 11 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-07-11 · Complement Ther Med · vol. 52 · pág. 102505
- Editorial
- Elsevier BV
- Citado
- 18 citas · más que el 57% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nuts composition and effects · Adipokines, Inflammation, and Metabolic Diseases · Nutritional Studies and Diet
- Palabras clave
- adiponectin, leptin, glycemic markers, fasting blood glucose, insulin, HbA1c, obesity, cardiometabolic disease, dietary intervention
- MeSH
- humans, juglans, insulin, leptin, blood glucose, adiponectin, randomized controlled trials as topic, biomarkers, glycated hemoglobin
9 autores
- Ling Yang
- Zhiyang GuoChinese People's Armed Police Force
- Shuwen QiChinese People's Armed Police Force
- Tao Fang
- Hongyan Zhu
- Heitor Oliveira Santos🇧🇷Universidade Federal de Uberlândia
- Vahid Khani🇮🇷Taleghani General Hospital; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Chun Hoong Wong🇲🇾Serdang Hospital
- Zhiyun Qiu🇨🇳 · autor de correspondenciaFudan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & objective
Walnut intake is considered a healthy dietary approach worldwide, particularly as a nutritional tool for the management of obesity and cardiometabolic disorders. Among these lines, leptin and adiponectin, as well as glycemic biomarkers, deserve further attention. We aimed to examine the impact of walnut intake on circulation levels of leptin and adiponectin through a systematic review and meta-analysis of randomized clinical trials (RCTs); secondarily, assessing the glycemic profile as well.
Methods
The literature search was implemented in four following databases: Web of Science, Scopus, PubMed/Medline, and Google Scholar, thus, determining studies that measured the effects of walnut consumption on adiponectin, leptin, and glycemic biomarkers levels from 2004 up to December 2019.
Results
Fourteen trials were include in the meta-analysis, with an intervention period ranging from 5 weeks to 12 months.Walnut intake increased leptin (weighted mean difference (WMD): 2.502 ng/mL; 95 % CI: 2.147-2.856, p < 0.001) and adiponectin (WMD: 0.440 ng/mL; 95 % CI: 0.323 to 0.557, p < 0.001) levels. Pertaining to glycemic biomarkers, neither overall analyses nor sub-analyses corroborated with changes in fasting blood glucose (WMD: 0.500 mg/dL, 95 % CI: -0.596, 1.596, p = 0.371), insulin (WMD: -0.21 mg/dL, 95 % CI: -0.67, 0.24, p = 0.367), and glycated hemoglobin (WMD: 0.004 mg/dL, 95 % CI: -0.041, 0.049, p = 0.870) concentrations.
Conclusion
Walnut intake may increase leptin and adiponectin levels but does not improve glycemic biomarkers.
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