Highland Barley Whole Grain (Hordeum vulgare L.) Ameliorates Hyperlipidemia by Modulating Cecal Microbiota, miRNAs, and AMPK Pathways in Leptin Receptor-Deficient db/db Mice
Deng N, He Z, Guo R, Zheng B, Li T, Liu RH
Journal of agricultural and food chemistry · 34 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Higher Education Discipline Innovation Project
- Gobierno
- Basic and Applied Basic Research Foundation of Guangdong Province
- Gobierno
- the Guangzhou Innovation Leading Talent Project
- Gobierno
- the Innovative Leading Talents Project of Guangzhou Development Zone
- Organización sin fines de lucro
- the 111 Project
- Gobierno
- the Guangdong Basic and Applied Basic Research Foundation
- Gobierno
- Natural Science Foundation of Guangdong Province, China
- Subvenciones
- Basic and Applied Basic Research Foundation of Guangdong Province (2020A1515011376); Higher Education Discipline Innovation Project (B1701 8)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2020-09-27 · J Agric Food Chem · vol. 68 · número 42 · págs. 11735–11746
- Editorial
- American Chemical Society
- Citado
- 47 citas · más que el 90% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- De pago
- Áreas de investigación
- Gut microbiota and health · Metabolomics and Mass Spectrometry Studies · Nutrition, Genetics, and Disease
- Palabras clave
- AMPK, Hyperlipidemia, Fatty acid synthase, Biology, Endocrinology, Internal medicine, Gut flora, Biochemistry, Lipid metabolism, Protein kinase A, Kinase, Medicine
- MeSH
- cecum, liver, animals, mice, knockout, humans, mice, bacteria, hordeum, seeds, disease models, animal, micrornas, male, sterol regulatory element binding protein 1, hyperlipidemias, receptors, leptin, amp-activated protein kinases, fatty acid synthases, gastrointestinal microbiome
6 autores
- Na Deng🇨🇳South China University of Technology
- Ziqian He🇨🇳South China University of Technology
- Ruixue Guo🇨🇳Guangdong Pharmaceutical University
- Bisheng Zheng🇨🇳 · autor de correspondenciaSouth China University of Technology
- Li Tong🇺🇸Cornell University
- Rui Hai Liu🇺🇸 · autor de correspondenciaCornell University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The mechanisms of highland barley whole grain (BWG) with rich phenolics on obese db/db mice were investigated in this study. Oral consumption of BWG reduced food intake, body weight, organ/body weight indexes of liver and fat, levels of serum and hepatic lipids, liver injury, and oxidative stress. Furthermore, BWG recovered the disorder of cecal microbiota by augmenting the Bacteroidetes/Firmicutes ratio and Alistipes abundance and decreasing the abundances of Bacteroides and Desulfovibrionaceae to modulate lipid metabolism-related genes. BWG inhibited fatty acid biosynthesis via upregulating the phosphorylation of AMP-activated protein kinase α, while downregulating sterol regulatory element binding protein-1c, fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 levels. BWG also significantly downregulated miRNA-122, miRNA-33, miRNA-34a, and miRNA-206 levels. Accordingly, BWG exhibited hypolipidemic potential through modulating cecal microbiota, AMPK/SREBP-1c/FAS pathway, and related miRNAs, triggering the alleviation of dyslipidemia. These findings suggested BWG as an effective candidate to ameliorate the symptoms of hyperlipidemia.
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