The Effect of Photobiomodulation on Nitrite and Inflammatory Activity in Radiotherapy-Induced Oral Mucositis: A Randomized Clinical Trial
Martins AFL, Morais MO, Sousa-Neto SS, Oton-Leite AF, Pereira CH, Valadares MC, Freitas NMA, Batista AC, Leles CR, Mendonça EF
Lasers in surgery and medicine · 17 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de Goiás/Ministério da Saúde/CNPq/Programa Pesquisa para o SUS
- Subvenciones
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (307906-7)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2020-09-30 · Lasers Surg Med · vol. 53 · número 5 · págs. 671–683
- Editorial
- Wiley
- Citado
- 24 citas · más que el 68% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 71 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Oral Health Pathology and Treatment
- Palabras clave
- low-level laser therapy, oral mucositis, radiotherapy, head and neck cancer, nitrite, inflammatory cytokines, interleukin-6, IL-10, interleukin-12p70, IL-1β, TNF-α, interleukin-8, preventive dentistry, salivary biomarkers, chemotherapy-induced mucositis
- MeSH
- saliva, humans, head and neck neoplasms, stomatitis, nitrites, low-level light therapy
10 autores
- Allisson Filipe Lopes Martins🇧🇷Hospital Araújo Jorge; Universidade Federal de Goiás
- Marília Oliveira Morais🇧🇷Hospital Araújo Jorge
- Sebastião Silvério Sousa‐Neto🇧🇷Hospital Araújo Jorge; Universidade Federal de Goiás
- Angélica Ferreira Oton‐Leite🇧🇷Hospital Araújo Jorge
- Carlos Henrique Pereira🇧🇷Hospital Araújo Jorge; Universidade Federal de Goiás
- Marize Campos Valadares🇧🇷Hospital Araújo Jorge; Universidade Federal de Goiás
- Nilceana Maya Aires Freitas🇧🇷Hospital Araújo Jorge; Universidade Federal de Goiás
- Aline Carvalho Batista🇧🇷Hospital Araújo Jorge; Universidade Federal de Goiás
- Cláudio Rodrigues Leles🇧🇷Hospital Araújo Jorge; Universidade Federal de Goiás
- Elismauro Francisco Mendonça🇧🇷 · autor de correspondenciaHospital Araújo Jorge; Universidade Federal de Goiás
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
To investigate pro- and anti-inflammatory cytokines and nitrite salivary levels in patients with head and neck cancer receiving photobiomodulation therapy (PBMT) associated with a Preventive Oral Care Program (POCP), for prevention and control of oral mucositis (OM) during radiotherapy (RT) associated or not with chemotherapy protocol.
Study design/materials and methods
In this randomized double-blinded clinical trial, 48 patients were randomly assigned to two groups: PBMT (n = 25) and Control (n = 23). In the PBMT group, patients were submitted to PBMT associated with the POCP. In the Control group, patients were submitted only to the POCP. Saliva samples were collected in the 1st (baseline), 7th, 14th, 21st, and 30th sessions of RT, and the levels of interleukin-6 (IL-6), IL-8, IL-10, IL-12p70, IL-1β, and tumoral necrosis factor-α (TNF-α) were measured using the cytometric bead array. Nitrite levels were measured by colorimetric method. OM was assessed using the World Health Organization and the National Cancer Institute scales.
Results
Patients in the PBMT group presented less severe OM. PBMT tended to stabilize nitrite concentration levels during the RT regimen. The IL-1β concentration was associated with higher OM scores. PBMT promoted an increase in IL-12p70, TNF-α, and IL-10 concentration.
Conclusion
PBMT was effective in the prevention and control of severe OM, and its mechanism of action may be related to a better balance of inflammatory response that may favor injury control. Lasers Surg. Med. © 2020 Wiley Periodicals LLC.
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