Photobiomodulation is effective in oral lichen planus: A randomized, controlled, double-blind study
Ferri EP, Cunha KRL, Abboud CS, de Barros Gallo C, de Sousa Sobral S, de Fatima Teixeira da Silva D, Horliana ACRT, Franco AL, Rodrigues MFSD
Oral diseases · 25 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Según 1 financiador declarado.
Publicación
- Publicado
- 2020-10-04 · Oral Dis · vol. 27 · número 5 · págs. 1205–1216
- Editorial
- Wiley
- Citado
- 27 citas · más que el 90% de estudios similares · 2.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Oral Health Pathology and Treatment · Laser Applications in Dentistry and Medicine · Oral health in cancer treatment
- Palabras clave
- low-level laser therapy, oral lichen planus, clobetasol propionate, topical corticosteroids, analgesia, clinical scoring systems, recurrence, non-invasive treatment, laser therapy
- MeSH
- humans, lichen planus, oral, clobetasol, glucocorticoids, treatment outcome, administration, topical, double-blind method
9 autores
- Elza Padilha Ferri🇧🇷Universidade Nove de Julho
- Karen Roberta Lopes Cunha🇧🇷Universidade Nove de Julho
- Clery Saad Abboud🇧🇷Universidade Nove de Julho
- Camila de Barros Gallo🇧🇷Universidade de São Paulo
- Sérgio de Sousa Sobral🇧🇷Universidade Nove de Julho
- Daniela de Fátima Teixeira da Silva🇧🇷Universidade Nove de Julho
- Anna Carolina Ratto Tempestini Horliana🇧🇷Universidade Nove de Julho
- Adriana Lino‐dos‐Santos‐Franco🇧🇷Universidade Nove de Julho
- Maria Fernanda Setúbal Destro Rodrigues🇧🇷 · autor de correspondenciaUniversidade Nove de Julho
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To compare the efficacy of photobiomodulation to that of topical clobetasol 0.05% in patients with symptomatic oral lichen planus (OLP).
Subjects
Thirty-four patients with symptomatic OLP were randomly allocated into two groups: (a) the Control group (n = 17), application of topical clobetasol propionate 0.05% three times a day for 30 consecutive days with laser placebo applied twice a week to mask the treatment, and (b) the photobiomodulation group (n = 17), laser application twice a week, totalling 8 sessions, and gel placebo for 30 consecutive days to mask the treatment. Evaluations were performed once a week during treatment and 30, 60 and 90 days after treatment. The following parameters were evaluated: pain, clinical scores, clinical resolution and recurrence rate.
Results
Photobiomodulation and propionate clobetasol 0.05% were able to significantly decrease pain in oral lichen planus patients and improve clinical scores during treatment and follow-up. Both the Control and photobiomodulation groups presented similar clinical resolution and recurrence rates. Most importantly, no difference was observed between treatments during treatment and follow-up.
Conclusions
These findings indicate that photobiomodulation twice a week is as effective as corticoid therapy in treating oral lichen planus. Moreover, photobiomodulation is a safe and non-invasive therapy with the remarkable advantage of no adverse effects.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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