The Effects of Music Intervention on Pallidum-DMN Circuit of Schizophrenia
Yao Y, He H, Duan M, Li S, Li C, Chen X, Yao G, Chang X, Shu H, Wang H, Luo C
BioMed research international · 13 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Sichuan Province Science and Technology Support Program
- Subvenciones
- National Natural Science Foundation of China (S17013); National Natural Science Foundation of China (Q19028); National Natural Science Foundation of China (2019YJ0651); Sichuan Province Science and Technology Support Program (2019YJ0179); National Natural Science Foundation of China (2016HH0005); Sichuan Province Science and Technology Support Program (2016HH0005); National Natural Science Foundation of China (2019YJ0179); National Natural Science Foundation of China (61761166001); National Natural Science Foundation of China (81471638)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-01-01 · Biomed Res Int · vol. 2020 · número 1 · pág. 4107065
- Editorial
- Hindawi Publishing Corporation
- Citado
- 17 citas · más que el 67% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Functional Brain Connectivity Studies · Neuroscience and Music Perception · Advanced Neuroimaging Techniques and Applications
- Palabras clave
- Functional magnetic resonance imaging, Schizophrenia (object-oriented programming), Psychology, Striatum, Globus pallidus, Audiology, Neuroscience, Resting state fMRI, Hippocampus, Ventral striatum, Anterior cingulate cortex, Psychiatry, Medicine, Cognition, Basal ganglia, Central nervous system
- MeSH
- cerebellum, gyrus cinguli, hippocampus, globus pallidus, neural pathways, humans, antipsychotic agents, magnetic resonance imaging, brain mapping, longitudinal studies, schizophrenia, rest, music, adult, middle aged, female, male
11 autores
- Yutong Yao🇨🇳University of Electronic Science and Technology of China
- Hui He🇨🇳 · autor de correspondenciaUniversity of Electronic Science and Technology of China
- Mingjun Duan🇨🇳 · autor de correspondenciaUniversity of Electronic Science and Technology of China
- Shicai Li🇨🇳University of Electronic Science and Technology of China
- Buwen Cheng🇨🇳University of Electronic Science and Technology of China
- Xi Chen🇨🇳University of Electronic Science and Technology of China
- Gang Yao🇨🇳University of Electronic Science and Technology of China
- Xin Long Chang🇨🇳University of Electronic Science and Technology of China
- Haifeng Shu🇨🇳University of Electronic Science and Technology of China
- Hongming Wang🇨🇳University of Electronic Science and Technology of China
- Cheng Luo🇨🇳 · autor de correspondenciaUniversity of Electronic Science and Technology of China
Resumen
El texto original del estudio, en el idioma en que se publicó.
Music intervention has been applied to improve symptoms of schizophrenic subjects as a complementary treatment in medicine. Although the psychiatric symptoms, especially for motivation and emotion, could be increased in schizophrenia, the underlying neural mechanisms remain poorly understood. We employed a longitudinal study to measure the alteration of striatum functional networks in schizophrenic subjects undergoing Mozart music listening using resting-state functional magnetic resonance imaging (fMRI). Forty-five schizophrenic inpatients were recruited and randomly assigned to two groups. Under the standard care with antipsychotic medication, one group received music intervention for 1 month and the other group is set as control. Both schizophrenic groups were compared to healthy subjects. Resting-state fMRI was acquired from schizophrenic subjects at baseline and after one-month music intervention and from healthy subjects at baseline. Striatum network was assessed through seed-based static and dynamic functional connectivity (FC) analyses. After music intervention, increased static FC was observed between pallidum and ventral hippocampus in schizophrenic subjects. Increased dynamic FCs were also found between pallidus and subregions of default mode network (DMN), including cerebellum crus and posterior cingulate cortex. Moreover, static pallidus-hippocampus FC increment was positively correlated with the improvement of negative symptoms in schizophrenic subjects. Together, these findings provided evidence that music intervention might have an effect on the FC of the striatum-DMN circuit and might be related to the remission of symptoms of schizophrenia.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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