An Almond-Based Low Carbohydrate Diet Improves Depression and Glycometabolism in Patients with Type 2 Diabetes through Modulating Gut Microbiota and GLP-1: A Randomized Controlled Trial
Ren M, Zhang H, Qi J, Hu A, Jiang Q, Hou Y, Feng Q, Ojo O, Wang X
Nutrients · 107 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Science and Technology Program of Suzhou
- Gobierno
- Suzhou Science and Technology Project, China
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-10-03 · Nutrients · vol. 12 · número 10 · pág. 3036
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 139 citas · más que el 98% de estudios similares · 7.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 59 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nuts composition and effects · Diet and metabolism studies · Agriculture Sustainability and Environmental Impact
- Palabras clave
- Type 2 diabetes, Gut flora, Depression (economics), Medicine, Internal medicine, Type 2 Diabetes Mellitus, Randomized controlled trial, Diabetes mellitus, Endocrinology, Immunology
- MeSH
- feces, humans, diabetes mellitus, type 2, blood glucose, treatment outcome, fasting, prospective studies, depression, aged, female, male, diet, carbohydrate-restricted, glucagon-like peptide 1, gastrointestinal microbiome, prunus dulcis, glycemic control, glycated hemoglobin
9 autores
- Mengxiao Ren🇨🇳Soochow University
- Huaiyu Zhang🇺🇸University of California, San Francisco
- Jindan Qi🇨🇳Soochow University
- Anni Hu🇨🇳Soochow University
- Qing Jiang🇨🇳Soochow University
- Yunying Hou🇨🇳Soochow University
- Qianqian Feng🇨🇳Soochow University
- Omorogieva Ojo🇬🇧University of Greenwich
- Xiaohua Wang🇨🇳 · autor de correspondenciaSoochow University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Alow carbohydrate diet (LCD) is more beneficial for the glycometabolism in type 2 diabetes (T2DM) and may be effective in reducing depression. Almond, which is a common nut, has been shown to effectively improve hyperglycemia and depression symptoms. This study aimed to determine the effect of an almond-based LCD (a-LCD) on depression and glycometabolism, as well as gut microbiota and fasting glucagon-like peptide 1 (GLP-1) in patients with T2DM.
Methods
This was a randomized controlled trial which compared an a-LCD with a low-fat diet (LFD). Forty-five participants with T2DM at a diabetes club and the Endocrine Division of the First and Second Affiliated Hospital of Soochow University between December 2018 to December 2019 completed each dietary intervention for 3 months, including 22 in the a-LCD group and 23 in the LFD group. The indicators for depression and biochemical indicators including glycosylated hemoglobin (HbA1c), gut microbiota, and GLP-1 concentration were assessed at the baseline and third month and compared between the two groups.
Results
A-LCD significantly improved depression and HbA1c (p Roseburia, Ruminococcus and Eubacterium. The GLP-1 concentration in the a-LCD group was higher than that in the LFD group (p <0.05).
Conclusions
A-LCD could exert a beneficial effect on depression and glycometabolism in patients with T2DM. We speculate that the role of a-LCD in improving depression in patients with T2DM may be associated with it stimulating the growth of SCFAs-producing bacteria, increasing SCFAs production and GPR43 activation, and further maintaining GLP-1 secretion. In future studies, the SCFAs and GPR43 activation should be further examined.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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