Effects of Intermittent Fasting or Calorie Restriction on Markers of Lipid Metabolism in Human Skeletal Muscle
Liu B, Hutchison AT, Thompson CH, Lange K, Wittert GA, Heilbronn LK
The Journal of clinical endocrinology and metabolism · 33 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Australian Research Council
- Gobierno
- National Health and Medical Research Council
- Subvenciones
- Australian Research Council (FT120100027); National Health and Medical Research Council (1023401)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2020-10-08 · J Clin Endocrinol Metab · vol. 106 · número 3 · págs. e1389–e1399
- Editorial
- Oxford University Press
- Citado
- 39 citas · más que el 88% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Muscle metabolism and nutrition · Muscle Physiology and Disorders
- Palabras clave
- intermittent fasting, caloric restriction, skeletal muscle lipid metabolism, free fatty acids, beta-hydroxybutyrate, insulin resistance, oxidative stress, antioxidant enzymes, glutathione peroxidase 1, superoxide dismutase, perilipin 5, fat deposition, obesity, weight loss, fat loss
- MeSH
- muscle, skeletal, mitochondria, muscle, humans, obesity, weight loss, caloric restriction, fasting, follow-up studies, oxidation-reduction, adult, aged, middle aged, female, overweight, lipid metabolism, biomarkers
6 autores
- Bo Liu🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Amy T. Hutchison🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Campbell Henry Thompson🇦🇺The University of Adelaide
- Kylie M. Lange🇦🇺The University of Adelaide
- Gary Wittert🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Leonie Kaye Heilbronn🇦🇺 · autor de correspondenciaSouth Australian Health and Medical Research Institute; The University of Adelaide
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Impaired lipid metabolism is linked with obesity-associated insulin resistance, which may be reversed by caloric restriction (CR).
Objective
In a secondary analysis of a randomized controlled trial, we compared the effects of intermittent fasting (IF) and CR on markers of lipid metabolism in muscle.
Design
Seventy-six women (body mass index, 25-40 kg/m2) were randomly assigned to 1 of 3 diets for 8 weeks and provided foods at 70% (CR70 and IF70) or 100% (IF100) of energy requirements. IF groups ate breakfast prior to a 24-hour fast on 3 nonconsecutive days per week. On nonfasting days, IF70 ate at 100% and IF100 ate at 145% of energy requirements to achieve the prescribed target. Weight, body composition, insulin sensitivity by clamp, nonesterified fatty acids (NEFAs), β-hydroxybutyrate (BHB), and markers of lipid metabolism and oxidative stress in muscle by quantitative polymerase chain reaction were measured at baseline and week 8 following a 12-hour overnight fast (all groups) and 24-hour fast (IF groups).
Results
IF70 resulted in greater weight and fat loss and reduced NEFAs vs CR70 and IF100 after an overnight fast. IF70 and IF100 induced a greater reduction only in mRNA levels of antioxidant enzymes glutathione peroxidase 1 (GPX1), superoxide dismutase 1, soluble (SOD1), and SOD2 vs CR70. Fasting for 24 hours increased NEFAs and BHB in IF groups, but impaired insulin sensitivity and increased PLIN5 mRNA levels.
Conclusions
In comparison to CR, IF did not increase markers of lipid metabolism in muscle, but reduced expression of antioxidant enzymes. However, fasting-induced insulin resistance was detected, alongside increased PLIN5 expression, potentially reflecting transient lipid storage.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.