Photobiomodulation Dose Parameters in Dentistry: A Systematic Review and Meta-Analysis
Cronshaw M, Parker S, Anagnostaki E, Mylona V, Lynch E, Grootveld M
Dentistry journal · 48 citas
Cómo se estudió
- Diseño
- Metaanálisis (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-10-06 · Dent J (Basel) · vol. 8 · número 4 · pág. 114
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 93 citas · más que el 91% de estudios similares · 2.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 89 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Oral health in cancer treatment · Photodynamic Therapy Research Studies
- Palabras clave
- Medicine, Mucositis, Clinical trial, Systematic review, Randomized controlled trial, Meta-analysis, MEDLINE, Dentistry, Radiation therapy, Surgery, Internal medicine
6 autores
- Mark Cronshaw🇬🇧 · autor de correspondenciaDe Montfort University; University of Birmingham
- Steven P. A. Parker🇬🇧De Montfort University
- Eugenia Anagnostaki🇬🇧De Montfort University
- Valina Mylona🇬🇧De Montfort University
- Edward J. Lynch🇺🇸🇬🇧University of Nevada, Las Vegas; De Montfort University
- Martin C. Grootveld🇺🇸🇬🇧University of Nevada, Las Vegas; De Montfort University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This systematic review and meta-analysis of published randomized controlled trials examines a possible relationship between optical spot size at surface tissue, irradiance, radiant exposure, total energy delivered, operator technique and reported clinical outcomes.
Background
Clinical photobiomodulation (PBM) therapy has achieved a high level of evidence-based acceptance in the mitigation of oral mucositis associated with cancer radiotherapy and chemotherapy, and supportive clinical research in relation to orthodontic tooth movement, oral medical conditions, including burning mouth syndrome, xerostomia and lichen planus. Inconsistent outcomes have been reported not withstanding a substantial body of primary supportive research from clinical, in vitro and animal studies.
Materials and methods
PubMed, Cochrane Database of Reviews and Google Scholar search engines were applied to identify human clinical trials of PBM therapy in clinical dentistry. A total of 766 articles between February 2009 and June 2020 were identified and following a full text evaluation, 38 papers with sufficient data to permit analyses are included in this investigation.
Results
Following a detailed assessment of potential factors that may have an influence in clinical outcome, a clear trend is apparent associating optical spot size to a positive or negative effect. Furthermore, there is a clear difference in the reported results in relation to total energy applied, delivery techniques and optical parameters, which merits further investigation. Factorial statistical analyses identified an association between smaller optical surface applications and an overall lower level of reported clinical success in treating superficial and deeper targets, and correspondingly sub-surface larger target tissues were found to be more responsive to therapy by use of a larger optical surface spot size. Moreover, use of multiple small diameter probe applications was found to provide inconsistent results.
Conclusions
Many factors can confound clinical success including variations in anatomy, site location, clinical condition and subject individuality. To achieve higher levels of predictable outcome, a mature appreciation of these factors, plus an expanded understanding of laser parametry, tissue volume and target depth to deliver an adequate dose within current recommended guidelines, is essential.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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