A Randomized Clinical Trial of Greek High Phenolic Early Harvest Extra Virgin Olive Oil in Mild Cognitive Impairment: The MICOIL Pilot Study
Tsolaki M, Lazarou E, Kozori M, Petridou N, Tabakis I, Lazarou I, Karakota M, Saoulidis I, Melliou E, Magiatis P
Journal of Alzheimer's disease : JAD · 65 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-10-09 · J Alzheimers Dis · vol. 78 · número 2 · págs. 801–817
- Editorial
- IOS Press
- Citado
- 86 citas · más que el 96% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- De pago
- Áreas de investigación
- Edible Oils Quality and Analysis · Nutritional Studies and Diet · Nuts composition and effects
- Palabras clave
- Olive oil, Mediterranean diet, Randomized controlled trial, Cognition, Medicine, Cognitive impairment, Cognitive decline, Internal medicine, Neuropsychology, Verbal fluency test, Effects of sleep deprivation on cognitive performance, Gastroenterology, Dementia, Psychiatry, Food science, Disease, Biology
- MeSH
- humans, phenols, magnetic resonance spectroscopy, cohort studies, longitudinal studies, prospective studies, pilot projects, double-blind method, neuropsychological tests, diet, mediterranean, aged, aged, 80 and over, middle aged, greece, female, male, olive oil, cognitive dysfunction
10 autores
- Magda Tsolaki🇬🇷 · autor de correspondenciaAristotle University of Thessaloniki; AHEPA University Hospital; Greek Association of Alzheimer's Disease and Related Disorders
- Eftychia Lazarou🇬🇷Greek Association of Alzheimer's Disease and Related Disorders
- Mahi Kozori🇬🇷Greek Association of Alzheimer's Disease and Related Disorders
- Niki Petridou🇬🇷Greek Association of Alzheimer's Disease and Related Disorders
- Irene-Maria Tabakis🇬🇷Aristotle University of Thessaloniki; AHEPA University Hospital
- Ioulietta Lazarou🇬🇷Aristotle University of Thessaloniki; AHEPA University Hospital
- Maria Karakota🇬🇷Greek Association of Alzheimer's Disease and Related Disorders
- Iordanis Saoulidis🇬🇷Aristotle University of Thessaloniki; AHEPA University Hospital
- Eleni Melliou🇬🇷National and Kapodistrian University of Athens
- Prokopios Magiatis🇬🇷National and Kapodistrian University of Athens
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Extra virgin olive oil (EVOO) constitutes a natural compound with high protection over cognitive function.
Objective
To investigate for the first time the effect of Greek High Phenolic Early Harvest Extra Virgin Olive Oil (HP-EH-EVOO) versus Moderate Phenolic (MP-EVOO) and Mediterranean Diet (MeDi) in people with mild cognitive impairment (MCI).
Methods
We conducted a randomized prospective study so as to examine the HP-EH-EVOO and MP-EVOO versus MeDi in MCI. Genetic predisposition (APOEɛ4) to Alzheimer's disease (AD) was tested and an extensive neuropsychological battery was administered at baseline and after 12 months. Each participant was randomized and assigned one of three groups: 1) Group 1 received the HP-EH-EVOO (50 mL/day); 2) Group 2 received the MP-EVOO (50 mL/day), and 3) Group 3 received only the MeDi instructions.
Results
Better follow-up performance was found in Group 1 compared to Group 2 and Group 3 in the almost all cognitive domains. Moreover, Group 2 showed also significant improvement compared to Group 3 in ADAS-cog (p = 0.001) and MMSE (p = 0.05), whereas Group 3 exhibited worse or similar to baseline performance in almost all domains. In particular, Group 1 and Group 2 had better outcomes with regards to ADAS-cog (p = 0.003), Digit Span (p = 0.006), and Letter fluency (p = 0.003). Moreover, there was a significant difference (p = 0.001) in the presence of APOEɛ4 between the Groups 1 and 2 versus Group 3.
Conclusion
Long-term intervention with HP-EH-EVOO or MP-EVOO was associated with significant improvement in cognitive function compared to MeDi, independent of the presence of APOEɛ4.
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