Photobiomodulation Enhances the Healing of Postextraction Alveolar Sockets: A Randomized Clinical Trial With Histomorphometric Analysis and Immunohistochemistry
Scarano A, Lorusso F, Postiglione F, Mastrangelo F, Petrini M
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 19 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-09-17 · J Oral Maxillofac Surg · vol. 79 · número 1 · págs. 57.e1–57.e12
- Editorial
- Elsevier BV
- Citado
- 23 citas · más que el 82% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Dental Implant Techniques and Outcomes · Periodontal Regeneration and Treatments
- Palabras clave
- low-level laser therapy, alveolar socket healing, third molar extraction, postoperative complications, alveolar mucosa, myofibroblasts, alpha-smooth muscle actin, desmin, immunohistochemistry, histomorphometry, inflammatory cells
- MeSH
- tooth socket, humans, tooth extraction, immunohistochemistry, prospective studies, wound healing, adolescent, female, male
5 autores
- Antônio Scarano🇮🇹 · autor de correspondenciaUniversity of Chieti-Pescara; Uningá - Centro Universitário Ingá
- Felice Lorusso🇮🇹University of Chieti-Pescara
- Francesca Postiglione🇮🇹University of Chieti-Pescara
- Filiberto Mastrangelo🇮🇹University of Foggia
- Morena Petrini🇮🇹University of Chieti-Pescara
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Wound healing of postextraction sockets is a complex process that permits to reach the bone reformation in about 3 months, and that could be characterized by the presence of some complications, mainly dependent on the duration of the surgery. The aim of this study is to evaluate the impact of photobiomodulation (PBMT) on the healing processes of mucosa overlying postextraction alveolus and on related complications.
Methods
Twenty systemically healthy patients who needed to extract both lower third molars were selected in a private clinic and included in this prospective split-mouth randomized clinical trial. Inclusion criteria were no smokers subjects with the necessity to extract both lower third molars with surgeries overlapping for duration and difficulty. A computer-based randomization procedure was permitted to choose the side, subject to PBMT, by means of a neodymium-doped YAG (Nd: YAG) laser (test) and controls. Both surgeries were performed by the same operator with a gap of 40 days. Twenty-two days after each surgery, a biopsy in correspondence to the alveolar mucosa of the socket was obtained from both sites and observed with an optical microscope and analyzed with histomorphometric analysis and immunohistochemistry.
Results
Each of the 20 participants included in this study (11 women and 9 men, nonsmokers, mean age 16 years in the range of 15 to 17 years) were subjected to the extraction of both lower third molars, and a side was treated as control, the other, as the test. The histomorphometric analysis and immunohistochemistry showed that the tested sites, contrary to controls, were characterized by a lower presence of inflammatory cells, a more mature epithelium and myofibroblasts incorporated in a network of fibers parallel to the basal membrane, with little positivity to alpha-SMA antibodies and anti-myosin but positivity to anti-desmin.
Conclusions
In conclusion, PBMT accelerates the healing process of postextraction alveolus after third molar extraction.
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