Leukocyte Activation and Antioxidative Defense Are Interrelated and Moderately Modified by n-3 Polyunsaturated Fatty Acid-Enriched Eggs Consumption-Double-Blind Controlled Randomized Clinical Study
Mihalj M, Stupin A, Kolobarić N, Bujak IT, Matić A, Kralik Z, Jukić I, Stupin M, Drenjančević I
Nutrients · 10 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- European Structural and Investment Funds grant for the Croatian National Scientific Center of Excellence for Personalized Health Care, University of Josip Juraj Strossmayer Osijek
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-10-13 · Nutrients · vol. 12 · número 10 · pág. 3122
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 13 citas · más que el 75% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 70 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Eicosanoids and Hypertension Pharmacology · Cardiovascular Disease and Adiposity
- Palabras clave
- Polyunsaturated fatty acid, Oxidative stress, Internal medicine, Endothelium, Biology, Endocrinology, Food science, Fatty acid, Biochemistry, Medicine
- MeSH
- endothelium, vascular, leukocytes, humans, fatty acids, omega-3, antioxidants, double-blind method, food analysis, lymphocyte activation, eating, eggs, adult, female, male, nutritional physiological phenomena, young adult
9 autores
- Martina Mihalj🇭🇷University of Osijek
- Ana Stupin🇭🇷University of Osijek
- Nikolina Kolobarić🇭🇷University of Osijek
- Ivana Tartaro Bujak🇭🇷University of Zagreb
- Anita Matić🇭🇷University of Osijek
- Zlata Kralik🇭🇷University of Osijek
- Ivana Jukić🇭🇷University of Osijek
- Marko Stupin🇭🇷University of Osijek
- Ines Drenjančević🇭🇷 · autor de correspondenciaUniversity of Osijek
Resumen
El texto original del estudio, en el idioma en que se publicó.
This placebo-controlled, double-blind, randomized, interventional study investigated the effects of low/intermediate doses of n-3 polyunsaturated fatty acids (PUFAs) on the endothelial function, markers of leukocyte activation, and oxidative status following dietary intake of n-3 PUFA-enriched hen eggs in young healthy individuals. Twenty young healthy adults of both sexes who consumed n-3 PUFA-enriched hen eggs (two eggs per day, for three weeks, total of approximately 407 mg/day n-3 PUFAs) or regular eggs (two eggs per day for three weeks, total of approximately 75 mg/day n-3 PUFAs) participated in this study. Skin microvascular endothelium-independent and endothelium-dependent vasodilation were assessed by laser Doppler flowmetry. Serum lipid profile and content of free fatty acids, markers of leukocyte activation, biochemical parameters of oxidative stress, as well as antioxidative enzymes serum activity were measured before and after respective dietary protocol. The results of this study revealed significant differences in the markers of leukocyte activation (such as CD11a/LFA-1) and antioxidative defense, which are related to increased intake of n-3 PUFAs, providing the evidence that consumption of nutritionally enriched hen eggs may affect physiological processes related to oxidative balance. The absence of significant changes in microvascular reactivity following supplementation with a low-intermediate dose of n-3 PUFAs, unlike in our previous studies where functional eggs contained ~1 g of n-3 PUFA, suggests the existence of a dose-dependent effect.
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