Blueberry and cardiovascular disease risk factors: A systematic review and meta-analysis of randomized controlled trials
Miraghajani M, Momenyan S, Arab A, Hasanpour Dehkordi A, Symonds ME
Complementary therapies in medicine · 12 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-04-11 · Complement Ther Med · vol. 53 · pág. 102389
- Editorial
- Elsevier BV
- Citado
- 32 citas · más que el 58% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Nutritional Studies and Diet · Natural Products and Biological Research
- Palabras clave
- blueberry, cardiovascular risk factors, plasma triglycerides, weight loss, functional foods, dietary supplements
- MeSH
- humans, lipids, tumor necrosis factor-alpha, c-reactive protein, body weights and measures, glycemic index, dietary supplements, randomized controlled trials as topic, blueberry plants, heart disease risk factors
5 autores
- Maryam Sadat Miraghajani🇬🇧🇮🇷 · autor de correspondenciaUniversity of Nottingham; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Somayeh Momenyan🇮🇷Qom University of Medical Science and Health Services
- Arman Arab🇮🇷Isfahan University of Medical Sciences
- Ali Hasanpour Dehkordi🇮🇷Shahrekord University; Shahrekord University of Medical Sciences
- Michael Edward Symonds🇬🇧 · autor de correspondenciaUniversity of Nottingham
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
Cardiovascular disease (CVD) remains an important cause of mortality and morbidity that can be prevented by the consumption of healthy foods. These include blueberry, a dark coloured berry containing extremely high amounts of functional ingredients. We therefore examined the extent to which supplementation with blueberry effects on CVD risk indices.
Methods
We searched the ISI Web of Science, Scopus, PubMed and Cochrane Library on March 2020 and checked reference lists from primary studies and review articles for any additional studies. No language restrictions were applied. All randomized and controlled clinical trials (RCTs) using blueberry supplements to modify CVD risk factors were included in our analysis.
Results
Mean Difference (MD) was pooled using a random effects model and 11 studies were included in the final analysis. Pooled effect size showed that supplementation with blueberry had a small insignificant effect in reducing plasma triglycerides (MD = -0.27 mmol/l; 95 % CI: -0.57, 0.17, p = 0.06). Although current study found no differences between blueberry and control groups for any other outcomes, subgroup analysis suggested a favourable impact of blueberry on reducing body weight. Significant weight loss was indicated from studies longer with a follow up of more than 6 weeks or with blueberry powder or freeze-dried blueberry.
Conclusion
Current evidence is insufficient to show a benefit of blueberry supplements in modifying CVD risk factors across a variety of adult populations. Robust data and larger studies are required to assess potential effects.
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