Wide awake at bedtime? Effects of caffeine on sleep and circadian timing in male adolescents - A randomized crossover trial
Reichert CF, Veitz S, Bühler M, Gruber G, Deuring G, Rehm SS, Rentsch K, Garbazza C, Meyer M, Slawik H, Lin YS, Weibel J
Biochemical pharmacology · 29 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Science Foundation
- Gobierno
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Gobierno
- Swiss National Science Foundation
- Subvenciones
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (171364)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2020-10-15 · Biochem Pharmacol · vol. 191 · pág. 114283
- Editorial
- Elsevier BV
- Citado
- 44 citas · más que el 84% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 114 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Coffee research and impacts · Sleep and related disorders · Circadian rhythm and melatonin
- Palabras clave
- caffeine, adolescents, sleep, circadian timing, slow-wave sleep, sleep quality, daytime sleepiness, melatonin onset, caffeine dose, interindividual variability
- MeSH
- brain, saliva, humans, melatonin, caffeine, central nervous system stimulants, cross-over studies, double-blind method, wakefulness, sleep, circadian rhythm, adolescent, male
12 autores
- Carolin Reichert🇨🇭 · autor de correspondenciaUniversity of Basel; Universitäre Psychiatrische Kliniken Basel
- Simon Veitz🇨🇭University of Basel; Universitäre Psychiatrische Kliniken Basel
- Miriam Bühler🇨🇭University of Basel; Universitäre Psychiatrische Kliniken Basel
- Georg Gruber🇦🇹Siesta Group (Austria)
- Gunnar Deuring🇨🇭University of Basel; Universitäre Psychiatrische Kliniken Basel
- Sophia Rehm🇨🇭University of Basel; University Hospital of Basel
- Katharina Rentsch🇨🇭University of Basel; University Hospital of Basel
- Corrado Garbazza🇨🇭University of Basel; Universitäre Psychiatrische Kliniken Basel
- Martin Meyer🇨🇭University of Basel; University Hospital of Basel; Universitäre Psychiatrische Kliniken Basel
- Helen Christina Slawik🇨🇭University of Basel; University Hospital of Basel; Universitäre Psychiatrische Kliniken Basel
- Yu-Shiuan Lin🇨🇭University of Basel; Universitäre Psychiatrische Kliniken Basel
- Janine Weibel🇨🇭University of Basel; Universitäre Psychiatrische Kliniken Basel
Resumen
El texto original del estudio, en el idioma en que se publicó.
Adolescents often suffer from short and mistimed sleep. To counteract the resulting daytime sleepiness they frequently consume caffeine. However, caffeine intake may exaggerate sleep problems by disturbing sleep and circadian timing. In a 28-hour double-blind randomized crossover study, we investigated to what extent caffeine disturbs slow-wave sleep (SWS) and delays circadian timing in teenagers. Following a 6-day ambulatory phase of caffeine abstinence and fixed sleep-wake cycles, 18 male teenagers (14-17 years old) ingested 80 mg caffeine vs. placebo in the laboratory four hours prior to an electro-encephalographically (EEG) recorded nighttime sleep episode. Data were analyzed using both frequentist and Bayesian statistics. The analyses suggest that subjective sleepiness is reduced after caffeine compared to placebo. However, we did not observe a strong caffeine-induced reduction in subjective sleep quality or SWS, but rather a high inter-individual variability in caffeine-induced SWS changes. Exploratory analyses suggest that particularly those individuals with a higher level of SWS during placebo reduced SWS in response to caffeine. Regarding salivary melatonin onsets, caffeine-induced delays were not evident at group level, and only observed in participants exposed to a higher caffeine dose relative to individual bodyweight (i.e., a dose > 1.3 mg/kg). Together, the results suggest that 80 mg caffeine are sufficient to induce alertness at a subjective level. However, particularly teenagers with a strong need for deep sleep might pay for these subjective benefits by a loss of SWS during the night. Thus, caffeine-induced sleep-disruptions might change along with the maturation of sleep need.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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