The effect of dietary nitrate on exercise capacity in chronic kidney disease: a randomized controlled pilot study
Ramick MG, Kirkman DL, Stock JM, Muth BJ, Farquhar WB, Chirinos JA, Doulias PT, Ischiropoulos H, Edwards DG
Nitric oxide : biology and chemistry · 10 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American College of Sports Medicine
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (R01HL113514); National Institutes of Health (HL113514)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2020-10-17 · Nitric Oxide · vol. 106 · págs. 17–23
- Editorial
- Elsevier BV
- Citado
- 14 citas · más que el 80% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 67 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Cardiovascular and exercise physiology · Nitric Oxide and Endothelin Effects · Exercise and Physiological Responses
- Palabras clave
- dietary nitrate, chronic kidney disease, exercise capacity, beetroot juice, nitric oxide metabolites, exercise intolerance, oxygen consumption, ventilatory threshold, skeletal muscle mitochondrial function, nitrate supplementation
- MeSH
- muscle, skeletal, humans, beta vulgaris, nitrates, exercise test, pilot projects, cross-over studies, double-blind method, exercise tolerance, dietary supplements, adult, aged, middle aged, female, male, renal insufficiency, chronic, fruit and vegetable juices
9 autores
- Meghan G. Ramick🇺🇸West Chester University; University of Delaware
- Danielle L. Kirkman🇺🇸Virginia Commonwealth University; University of Delaware
- Joseph M. Stock🇺🇸University of Delaware
- Bryce J. Muth🇺🇸Stockton University; University of Delaware
- William B. Farquhar🇺🇸University of Delaware
- Julio A. Chirinos🇺🇸University of Pennsylvania
- Paschalis‐Thomas Doulias🇺🇸🇬🇷Children's Hospital of Philadelphia; University of Ioannina
- Harry Ischiropoulos🇺🇸🇬🇷Children's Hospital of Philadelphia; University of Ioannina
- David G. Edwards🇺🇸 · autor de correspondenciaUniversity of Delaware
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Chronic Kidney Disease (CKD) patients exhibit a reduced exercise capacity that impacts quality of life. Dietary nitrate supplementation has been shown to have favorable effects on exercise capacity in disease populations by reducing the oxygen cost of exercise. This study investigated whether dietary nitrates would acutely improve exercise capacity in CKD patients.
Methods and results
In this randomized, double-blinded crossover study, 12 Stage 3-4 CKD patients (Mean ± SEM: Age, 60 ± 5yrs; eGFR, 50.3 ± 4.6 ml/min/1.73 m2) received an acute dose of 12.6 mmol of dietary nitrate in the form of concentrated beetroot juice (BRJ) and a nitrate depleted placebo (PLA). Skeletal muscle mitochondrial oxidative function was assessed using near-infrared spectroscopy. Cardiopulmonary exercise testing was performed on a cycle ergometer, with intensity increased by 25 W every 3 min until volitional fatigue. Plasma nitric oxide (NO) metabolites (NOm; nitrate, nitrite, low molecular weight S-nitrosothiols, and metal bound NO) were determined by gas-phase chemiluminescence. Plasma NOm values were significantly increased following BRJ (BRJ vs. PLA: 1074.4 ± 120.4 μM vs. 28.4 ± 6.6 μM, p 2peak (p = 0.35).
Conclusions
Our findings demonstrate that inorganic nitrate can acutely improve exercise capacity in CKD patients. The effects of chronic nitrate supplementation on CKD related exercise intolerance should be investigated in future studies.
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