Safety and efficacy of photobiomodulation therapy in oncology: A systematic review
Bensadoun RJ, Epstein JB, Nair RG, Barasch A, Raber-Durlacher JE, Migliorati C, Genot-Klastersky MT, Treister N, Arany P, Lodewijckx J, Robijns J, World Association for Laser Therapy (WALT)
Cancer medicine · 73 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-10-26 · Cancer Med · vol. 9 · número 22 · págs. 8279–8300
- Editorial
- Wiley
- Citado
- 114 citas · más que el 92% de estudios similares · 2.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 102 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Photodynamic Therapy Research Studies · Oral health in cancer treatment
- Palabras clave
- Medicine, Clinical trial, Systematic review, MEDLINE, Meta-analysis, In vivo, Cancer, Oncology, Head and neck cancer, Adverse effect, Internal medicine, Intensive care medicine, Biotechnology
- MeSH
- animals, humans, neoplasms, treatment outcome, tumor burden, cell differentiation, cell proliferation, low-level light therapy
11 autores
- René‐Jean Bensadoun🇫🇷 · autor de correspondenciaCentre de Haute Energie
- Joel Brian Epstein🇺🇸City of Hope; Sinai Health System
- RAJ G. NAIR🇦🇺Griffith University; Queensland Health; Gold Coast Hospital; Gold Coast Health
- Andrei Barasch🇺🇸Cambridge Health Alliance
- Judith E. Raber‐Durlacher🇳🇱Academic Center for Dentistry Amsterdam; Amsterdam University Medical Centers; Amsterdam University of Applied Sciences; Vrije Universiteit Amsterdam; University of Amsterdam
- Cesar Augusto Migliorati🇺🇸University of Florida
- M. T. Genot-Klastersky🇧🇪Institut Jules Bordet
- Nathaniel Simon Treister🇺🇸Harvard University
- Praveen Ravindra Arany🇺🇸University at Buffalo, State University of New York
- Joy Lodewijckx🇧🇪Hasselt University
- Jolien Robijns🇧🇪Hasselt University
Resumen
El texto original del estudio, en el idioma en que se publicó.
We performed a systematic review of the current literature addressing the safety and efficacy of photobiomodulation therapy (PBMT) in cancer patients. In this systematic review, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used. In vitro, in vivo, and clinical studies, which investigated the effect of PBMT on cell proliferation/differentiation, tumor growth, recurrence rate, and/or overall survival were included. The Medline/PubMed, EMBASE, and Scopus databases were searched through April 2020. A total of 67 studies met the inclusion criteria with 43 in vitro, 15 in vivo, and 9 clinical studies identified. In vitro studies investigating the effect of PBMT on a diverse range of cancer cell lines demonstrated conflicting results. This could be due to the differences in used parameters and the frequency of PBM applications. In vivo studies and clinical trials with a follow-up period demonstrated that PBMT is safe with regards to tumor growth and patient advantage in the prevention and treatment of specific cancer therapy-related complications. Current human studies, supported by most animal studies, show safety with PBMT using currently recommended clinical parameters, including in Head & Neck cancer (HNC) in the area of PBMT exposure. A significant and growing literature indicates that PBMT is safe and effective, and may even offer a benefit in patient overall survival. Nevertheless, continuing research is indicated to improve understanding and provide further elucidation of remaining questions regarding PBM use in oncology.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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