The effects of Canola oil on cardiovascular risk factors: A systematic review and meta-analysis with dose-response analysis of controlled clinical trials
Amiri M, Raeisi-Dehkordi H, Sarrafzadegan N, Forbes SC, Salehi-Abargouei A
Nutrition, metabolism, and cardiovascular diseases : NMCD · 34 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Shahid Sadoughi University of Medical Sciences
Según 1 financiador declarado.
Publicación
- Publicado
- 2020-06-18 · Nutr Metab Cardiovasc Dis · vol. 30 · número 12 · págs. 2133–2145
- Editorial
- Elsevier BV
- Citado
- 47 citas · más que el 71% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 121 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Coconut Research and Applications · Edible Oils Quality and Analysis
- Palabras clave
- Meta-analysis, Canola, Medicine, Clinical trial, Internal medicine, Biology
- MeSH
- humans, cardiovascular diseases, treatment outcome, risk assessment, risk reduction behavior, energy intake, nutritive value, randomized controlled trials as topic, recommended dietary allowances, protective factors, rapeseed oil, diet, healthy, cardiometabolic risk factors
5 autores
- Mojgan Amiri🇮🇷Shahid Sadoughi University of Medical Sciences and Health Services
- Hamidreza Raeisi‐Dehkordi🇮🇷Shahid Sadoughi University of Medical Sciences and Health Services
- Nizal Sarrafzadegan🇮🇷🇨🇦Isfahan University of Medical Sciences; University of British Columbia
- Scott C. Forbes🇨🇦Brandon University
- Amin Salehi‐Abargouei🇮🇷 · autor de correspondenciaShahid Sadoughi University of Medical Sciences and Health Services
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
Canola oil (CO) is a plant-based oil with the potential to improve several cardiometabolic risk factors. We systematically reviewed controlled clinical trials investigating the effects of CO on lipid profiles, apo-lipoproteins, glycemic indices, inflammation, and blood pressure compared to other edible oils in adults.
Methods and results
Online databases were searched for articles up to January 2020. Forty-two articles met the inclusion criteria. CO significantly reduced total cholesterol (TC, -0.27 mmol/l, n = 37), low-density lipoprotein cholesterol (LDL-C, -0.23 mmol/l, n = 35), LDL-C to high-density lipoprotein cholesterol ratio (LDL/HDL, -0.21, n = 10), TC/HDL (-0.13, n = 15), apolipoprotein B (Apo B, -0.03 g/l, n = 14), and Apo B/Apo A-1 (-0.02, n = 6) compared to other edible oils (P < 0.05). Compared to olive oil, CO decreased TC (-0.23 mmol/l, n = 9), LDL-C (-0.17 mmol/l, n = 9), LDL/HDL (-0.39, n = 2), and triglycerides in VLDL (VLDL-TG, -0.10 mmol/l, n = 2) (P < 0.05). Compared to sunflower oil, CO improved LDL-C (-0.14 mmol/l, n = 11), and LDL/HDL (-0.30, n = 3) (P < 0.05). In comparison with saturated fats, CO improved TC (-0.59 mmol/l, n = 11), TG (-0.08 mmol/l, n = 11), LDL-C (-0.49 mmol/l, n = 10), TC/HDL (-0.29, n = 5), and Apo B (-0.09 g/l, n = 4) (P < 0.05). Based on the nonlinear dose-response curve, replacing CO with ~15% of total caloric intake provided the greatest benefits.
Conclusion
CO significantly improved different cardiometabolic risk factors compared to other edible oils. Further well-designed clinical trials are warranted to confirm the dose-response associations.
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