Probable positive effects of the photobiomodulation as an adjunctive treatment in COVID-19: A systematic review
Nejatifard M, Asefi S, Jamali R, Hamblin MR, Fekrazad R
Cytokine · 30 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Animales
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-10-12 · Cytokine · vol. 137 · pág. 155312
- Editorial
- Elsevier BV
- Citado
- 56 citas · más que el 86% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Photodynamic Therapy Research Studies · COVID-19 Clinical Research Studies
- Palabras clave
- low-level laser therapy, COVID-19 pandemic, acute respiratory distress syndrome, lung inflammation, pulmonary edema, neutrophil infiltration, inflammatory cytokines, anti-inflammatory activity, tissue regeneration, infrared laser therapy, light-emitting diodes, oxygenation, animal models
- MeSH
- lung, neutrophils, macrophages, humans, pneumonia, pulmonary edema, reactive oxygen species, cytokines, pubmed, low-level light therapy, respiratory distress syndrome, covid-19
5 autores
- Marzieh Nejatifard🇮🇷Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Sohrab Asefi🇮🇷Tehran University of Medical Sciences
- Raika Jamali🇮🇷Sina Hospital; Tehran University of Medical Sciences
- Michael R. Hamblin🇿🇦 · autor de correspondenciaUniversity of Johannesburg
- Reza Fekrazad🇮🇷 · autor de correspondenciaAja University of Medical Sciences; Universal Scientific Education and Research Network
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
COVID-19, as a newly-emerged viral infection has now spread all over the world after originating in Wuhan, China. Pneumonia is the hallmark of the disease, with dyspnea in half of the patients and acute respiratory distress syndrome (ARDS) in up to one -third of the cases. Pulmonary edema, neutrophilic infiltration, and inflammatory cytokine release are the pathologic signs of this disease. The anti-inflammatory effect of the photobiomodulation (PBM) has been confirmed in many previous studies. Therefore, this review study was conducted to evaluate the direct effect of PBM on the acute lung inflammation or ARDS and also accelerating the regeneration of the damaged tissues. The indirect effects of PBM on modulation of the immune system, increasing the blood flow and oxygenation in other tissues were also considered.
Methodology
The databases of PubMed, Cochrane library, and Google Scholar were searched to find the relevant studies. Keywords included the PBM and related terms, lung inflammation, and COVID-19 -related signs. Studies were categorized with respect to the target tissue, laser parameters, and their results.
Results
Seventeen related papers were included in this review. All of them were in animal models. They showed that the PBM could significantly decrease the pulmonary edema, neutrophil influx, and generation of pro-inflammatory cytokines (tumor necrosis factor-α (TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6), intracellular adhesion molecule (ICAM), reactive oxygen species (ROS), isoform of nitric oxide synthase (iNOS), and macrophage inflammatory protein 2 (MIP-2)).
Conclusion
Our findings revealed that the PBM could be helpful in reducing the lung inflammation and promoting the regeneration of the damaged tissue. PBM can increase the oxygenation indirectly in order to rehabilitate the affected organs. Thus, the infra-red lasers or light-emitting diodes (LEDs) are recommended in this regard.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.