CYP1A2 genotype and acute ergogenic effects of caffeine intake on exercise performance: a systematic review
Grgic J, Pickering C, Del Coso J, Schoenfeld BJ, Mikulic P
European journal of nutrition · 31 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-11-02 · Eur J Nutr · vol. 60 · número 3 · págs. 1181–1195
- Editorial
- Springer Science+Business Media
- Citado
- 37 citas · más que el 72% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 58 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Genetics and Physical Performance · Pharmacogenetics and Drug Metabolism
- Palabras clave
- caffeine, ergogenic aids, exercise performance, genetic variation, caffeine metabolism, cardiorespiratory fitness, high-intensity exercise, resistance training, cycling time trial, caffeine supplementation
- MeSH
- humans, caffeine, cytochrome p-450 cyp1a2, eating, physical endurance, genotype, male, performance-enhancing substances
5 autores
- Jozo Grgić🇦🇺 · autor de correspondenciaVictoria University
- Craig Pickering🇬🇧University of Lancashire
- Juan Del Coso🇪🇸Universidad Rey Juan Carlos
- Brad Jon Schoenfeld🇺🇸Lehman College
- Pavle Mikulić🇭🇷University of Zagreb
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To systematically review studies that examined the influence of the CYP1A2 -163C>A polymorphism on the ergogenic effects of caffeine and to discuss some of the reasons for the discrepancies in findings between the studies.
Methods
This review was performed in accordance with the PRISMA guidelines. The search for studies was performed through nine databases.
Results
Seventeen studies were included in the review. Based on the included studies, it seems that individuals with the AA or AC/CC genotype may experience an increase in performance following caffeine ingestion. Significant differences between genotypes were found in four studies, and all four reported a more favorable response in the AA vs. AC/CC genotype. These results suggest that if there is an actual genotype-related effect of acute caffeine supplementation, it might be in that direction. In the studies that reported such data for aerobic endurance, the findings are specific to male participants performing cycling time trials (distances of ≥ 10 km) and ingesting caffeine 60 min before exercise. For high-intensity exercise, two studies reported that genotype variations determined the response to caffeine ingestion, even though the differences were either small (~ 1 additional repetition in high-load resistance exercise set performed to muscular failure) or inconsistent (i.e., observed only in one out of eight performance tests).
Conclusions
CYP1A2 genotype variations may modulate caffeine's ergogenic effects, but the differences between genotypes were small, inconsistent, or limited to specific exercise scenarios. Future studies with larger sample sizes are needed to fully elucidate this research area.
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