Clinical correlates of serum 25-hydroxyvitamin D in Parkinson's disease
Barichella M, Cereda E, Iorio L, Pinelli G, Ferri V, Cassani E, Bolliri C, Caronni S, Pusani C, Schiaffino MG, Giana A, Quacci E, Esposito C, Monti Guarnieri F, Colombo A, Sorbo FD, Cilia R, Sacilotto G, Riboldazzi G, Zecchinelli AL, Pezzoli G
Nutritional neuroscience · 11 citas
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Fondazione Grigioni per il Morbo di Parkinson
- Organización sin fines de lucro
- Brain and Malnutrition in Chronic Disease Association Onlus
Según 2 financiadores declarados.
Publicación
- Publicado
- 2020-11-05 · Nutr Neurosci · vol. 25 · número 6 · págs. 1128–1136
- Editorial
- Taylor & Francis
- Citado
- 24 citas · más que el 84% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Parkinson's Disease Mechanisms and Treatments · Biotin and Related Studies
- Palabras clave
- Vitamin D and neurology, Internal medicine, Medicine, Parkinson's disease, vitamin D deficiency, Gastroenterology, Population, Disease, Rating scale, Dopaminergic, Psychology, Dopamine
- MeSH
- humans, parkinson disease, calcifediol, vitamin d, cross-sectional studies
21 autores
- Michela Barichella🇮🇹Istituto Ortopedico Gaetano Pini; Grigioni Foundation for Parkinson's disease
- Emanuele Cereda🇮🇹 · autor de correspondenciaPoliclinico San Matteo Fondazione; Istituti di Ricovero e Cura a Carattere Scientifico
- Laura Iorio
- Giovanna Pinelli🇮🇹Istituto Ortopedico Gaetano Pini; Grigioni Foundation for Parkinson's disease
- Valentina Ferri🇮🇹Istituto Ortopedico Gaetano Pini; Grigioni Foundation for Parkinson's disease
- Erica Cassani🇮🇹Grigioni Foundation for Parkinson's disease
- Carlotta Bolliri🇮🇹Istituto Ortopedico Gaetano Pini; Grigioni Foundation for Parkinson's disease
- Serena Caronni🇮🇹Istituto Ortopedico Gaetano Pini; Grigioni Foundation for Parkinson's disease
- Chiara Pusani🇮🇹Istituto Ortopedico Gaetano Pini
- Maria Giulia Schiaffino🇮🇹University of Milan; Istituto Ortopedico Gaetano Pini
- Angelica Giana🇮🇹University of Milan; Istituto Ortopedico Gaetano Pini
- Elena Quacci🇮🇹University of Milan; Istituto Ortopedico Gaetano Pini
- Caterina Esposito🇮🇹University of Milan; Istituto Ortopedico Gaetano Pini
- Francesca Monti Guarnieri🇮🇹University of Milan; Istituto Ortopedico Gaetano Pini
- Aurora Colombo🇮🇹Istituto Ortopedico Gaetano Pini; Grigioni Foundation for Parkinson's disease
- Francesca Del Sorbo🇮🇹Istituto Ortopedico Gaetano Pini
- Roberto Cilia🇮🇹Istituto Ortopedico Gaetano Pini; Fondazione IRCCS Istituto Neurologico Carlo Besta
- Giorgio Sacilotto🇮🇹Istituto Ortopedico Gaetano Pini
- Giulio Riboldazzi
- Anna Zecchinelli🇮🇹Istituto Ortopedico Gaetano Pini
- Gianni Pezzoli🇮🇹Istituto Ortopedico Gaetano Pini; Grigioni Foundation for Parkinson's disease
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Parkinson's disease (PD) patients have lower levels of serum 25-hydroxyvitamin D (25(OH)D) than the general population. Previous studies have suggested a negative association between 25(OH)D and clinical features of PD, but the data are inconsistent.
Materials and methods
We conducted a cross-sectional, observational study. Serum 25(OH)D, disease (Hoehn-Yahr stage [HY]) and clinical symptom (Unified Parkinson Disease Rating Scale [UPDRS]) severity and global cognitive functions (Mini-Mental State Examination [MMSE]) were studied in 500 consecutive PD patients not using vitamin D supplements. Information on sunlight exposure and dietary intakes (using a 66-item food frequency questionnaire) were also collected. A convenient sample of age and sex-matched community healthy controls (N = 100) was included as a control group.
Results
PD patients had lower 25(OH)D serum levels than controls. Deficiency status (P = .002) and vitamin D intake (P = .009). In multivariate models, using a Mendelian randomization approach, lower serum 25(OH)D was associated with more severe disease (HY, P = .035), worse clinical symptoms (UPDRS Part-III total score [P = .006] and dopaminergic [P = .033] and non-dopaminergic subscores [P = .001]) and greater global cognitive function impairment (P = .041). Neither cognitive functions nor clinical features were associated with reduced intake of vitamin D and sunlight exposure.
Conclusion
: Serum 25(OH)D was negatively correlated with disease and symptoms severity, as well as with global cognitive functions. Our study adds to the evidence that low 25(OH)D may affect the progression of PD negatively. Intervention studies in this area are required.
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