Relationship between dietary magnesium intake and rheumatoid arthritis in US women: a cross-sectional study
Hu C, Zhu F, Liu L, Zhang M, Chen G
BMJ open · 13 citas
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Sin clasificar
- Strong
- Universidad u hospital
- Guangzhou University of Chinese Medicine
- Universidad u hospital
- Guangzhou University
- Universidad u hospital
- the Innovative and Strong Hospital Phase II Project of the First Affiliated Hospital of Guangzhou University of Chinese Medicine
- Gobierno
- the Science and Technology Program of Guangzhou
- Gobierno
- the Chinese National Natural Science Foundation Project
- Subvenciones
- Guangzhou University of Chinese Medicine (211010010705)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-11-01 · BMJ Open · vol. 10 · número 11 · pág. e039640
- Editorial
- BMJ
- Citado
- 17 citas · más que el 73% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Bone Metabolism and Diseases
- Palabras clave
- Medicine, Rheumatoid arthritis, National Health and Nutrition Examination Survey, Cross-sectional study, Magnesium, Internal medicine, Logistic regression, Dietary Reference Intake, Gastroenterology, Nutrient, Environmental health, Population, Pathology
- MeSH
- humans, arthritis, rheumatoid, magnesium, diet, nutrition surveys, cross-sectional studies, nutritional status, adult, aged, middle aged, female
5 autores
- Congqi Hu🇨🇳Guangzhou University of Chinese Medicine
- Fangfang Zhu🇨🇳Guangzhou University of Chinese Medicine
- Lijuan Liu🇨🇳First Affiliated Hospital of Guangzhou University of Chinese Medicine
- Mingying Zhang🇨🇳First Affiliated Hospital of Guangzhou University of Chinese Medicine
- Guangxing Chen🇨🇳 · autor de correspondenciaGuangzhou University of Chinese Medicine; First Affiliated Hospital of Guangzhou University of Chinese Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Diet has been shown to be associated with rheumatoid arthritis (RA), and magnesium has been shown to inhibit inflammatory responses, but research on the relationship between dietary magnesium and RA is limited and controversial. In this study, we aimed to explore the non-linear relationship between dietary magnesium intake and RA in US women.
Design
Cross-sectional survey.
Setting
National Health and Nutrition Examination Survey (NHANES).
Primary and secondary outcome measures
Non-linear relationship between dietary magnesium intake and prevalence of RA.
Participants
A total of 13 324 women aged 18-80 years (RA n=12 306, non-RA n=1018) were included in this study.
Results
Overall, the absolute risk (AR) of RA was 7.24% in all participants. In the multivariable logistic regression analysis, we found a negative correlation between dietary magnesium intake and RA (OR=0.84, 95% CI 0.75 to 0.95, p=0.006). When we converted dietary magnesium intake into a categorical variable (tertiles), the ARs of the low group, the middle group and the high group were 9%, 7.1% and 4.9%, respectively. We noticed that the ORs between the three groups were not equidistant; then, we detected a U-shaped linking by smooth curve fitting and obtained inflection points at 181 and 446 mg/day. The prevalence of RA decreased when dietary magnesium intake was 446 mg/day (OR=2.8, 95% CI 1.2 to 6.6, p=0.020), remaining at a minimum when it was between 181 and 446 mg/day (OR=1.0, 95% CI 0.7 to 1.2, p=0.700).
Conclusion
There was a U-shaped relationship between dietary magnesium and RA in women, and our study highlights the importance of moderate dietary magnesium intake in possibly exerting a protective role in women with RA.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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