Financiado en parte por Sanofi
Impact of magnesium supplementation, in combination with vitamin B6, on stress and magnesium status: secondary data from a randomized controlled trial
Noah L, Pickering G, Mazur A, Dubray C, Hitier S, Dualé C, Pouteau E
Magnesium research · 9 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Sanofi
Según 1 financiador declarado.
Publicación
- Publicado
- 2020-08-01 · Magnes Res · vol. 33 · número 3 · págs. 45–57
- Editorial
- John Libbey Eurotext
- Citado
- 14 citas · más que el 77% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Magnesium in Health and Disease · Therapeutic Uses of Natural Elements · Aluminum toxicity and tolerance in plants and animals
- Palabras clave
- Magnesium, Internal medicine, Vitamin, Randomized controlled trial, Magnesium deficiency (plants), Medicine, Vitamin C, Endocrinology, Vitamin b6, Gastroenterology, Chemistry
- MeSH
- humans, magnesium, vitamin b 6, dietary supplements, adolescent, adult, middle aged, young adult
7 autores
- Lionel Noah🇫🇷Sanofi (France)
- Gisele P Pickering🇫🇷Inserm; University of Clermont Auvergne; Centre Hospitalier Universitaire de Clermont-Ferrand
- Andrzej Mazur🇫🇷Université Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Centre de Recherche en Nutrition Humaine d'Auvergne
- Claude Dubray🇫🇷Inserm; University of Clermont Auvergne; Centre Hospitalier Universitaire de Clermont-Ferrand
- Simon Hitier🇫🇷Sanofi (France)
- Christian Dualé🇫🇷Inserm; University of Clermont Auvergne; Centre Hospitalier Universitaire de Clermont-Ferrand
- Etienne B. Pouteau🇫🇷Sanofi (France)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Primary findings from a recent study reported that magnesium supplementation significantly reduced stress in severely stressed subjects with low magnesemia, and additional vitamin B6 enhanced this effect. The mechanism by which combining magnesium and vitamin B6 leads to reduced stress in these subjects remains to be elucidated. This secondary analysis investigated the impact of magnesium and vitamin B6 supplementation and perceived stress on erythrocyte magnesium levels, as a marker of body magnesium status. This was a secondary analysis from an 8-week randomized controlled trial comparing oral magnesium (300 mg) and magnesium-vitamin B6 (300 mg + 30 mg) supplementation. Stress level and erythrocyte magnesium level at baseline, and change in erythrocyte magnesium and serum vitamin B6 levels at weeks 4 and 8, were analyzed. Overall, 264 subjects were randomized to treatment and had evaluable Depression Anxiety Stress Scale scores (132 in each treatment arm). At baseline, stress scores, and mean serum magnesium, erythrocyte magnesium, and serum vitamin B6 concentrations were similar between arms. Although not significant between groups, a significant increase over time in erythrocyte magnesium levels was observed in the subgroup of subjects with low baseline erythrocyte magnesium levels (<1.6 mmol/L) following treatment with magnesium and magnesium-vitamin B6 (week 4:0.21 mmol/L [95% confidence interval (CI), 0.10 to 0.31], p = 0.0003; and 0.13 mmol/L [95% CI, 0.02 to 0.23], p = 0.0233, respectively). Change from baseline in circulating vitamin B6 levels at weeks 4 and 8 in the magnesium-vitamin B6 supplemented group (314.96 nmol/L [95%CI, 294.61 to 335.31]) was significantly different (p < 0.0001) compared with the magnesium supplemented group (-0.39 nmol/L [95% CI, -20.73 to 19.94]). Magnesium alone and magnesium-vitamin B6 provided statistically significant increases in erythrocyte magnesium in subjects with low magnesium status (<1.6mmol/L). Vitamin B6 supplementation did not further increase magnesium levels.
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