Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials
Liu C, Kuang X, Li K, Guo X, Deng Q, Li D
Food & function · 115 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- National Key Research and Development Program of China
- Subvenciones
- National Key Research and Development Program of China (2015CB553604); National Natural Science Foundation of China (NSFC: 81773433)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2020-01-01 · Food Funct · vol. 11 · número 12 · págs. 10817–10827
- Editorial
- Royal Society of Chemistry
- Citado
- 160 citas · más que el 96% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- De pago
- Áreas de investigación
- Bone health and osteoporosis research · Vitamin D Research Studies · Vitamin K Research Studies
- Palabras clave
- osteoporosis, postmenopausal women, calcium supplementation, vitamin D supplementation, bone mineral density, femoral neck, lumbar spine, dairy products, hip fracture prevention
- MeSH
- lumbar vertebrae, humans, osteoporosis, postmenopausal, calcium, dietary, calcium, vitamin d, postmenopause, bone density, dairy products, dietary supplements, databases, factual, female, bone density conservation agents, fractures, bone, randomized controlled trials as topic
6 autores
- Chunxiao Liu🇨🇳Qingdao University
- Xiaotong Kuang🇨🇳Qingdao University
- Kelei Li🇨🇳Qingdao University
- Xiaofei Guo🇨🇳Qingdao University
- Qingxue Deng🇨🇳Qingdao University
- Duo Li🇨🇳 · autor de correspondenciaQingdao University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The aim of the present study was to explore whether combined calcium and vitamin D supplementation is beneficial for osteoporosis in postmenopausal women.
Methods
We searched the PubMed, Cochrane library, Web of science and Embase databases and reference lists of eligible articles up to Feb, 2020. Randomized controlled trials (RCTs) evaluating the effect of combined calcium and vitamin D on osteoporosis in postmenopausal women were included in the present study.
Results
Combined calcium and vitamin D significantly increased total bone mineral density (BMD) (standard mean differences (SMD) = 0.537; 95% confidence interval (CI): 0.227 to 0.847), lumbar spine BMD (SMD = 0.233; 95% CI: 0.073 to 0.392; P -1 (SMD = 0.335; 95% CI: 0.113 to 0.558), but not for a dose more than 400 IU d-1 (SMD = -0.098; 95% CI: -0.109 to 0.305), and calcium had no effect on the femoral neck BMD. Subgroup analysis also showed only dairy products fortified with calcium and vitamin D had a significant influence on total BMD (SMD = 0.784; 95% CI: 0.322 to 1.247) and lumbar spine BMD (SMD = 0.320; 95% CI: 0.146 to 0.494), but not for combined calcium and vitamin D supplement.
Conclusion
Dairy products fortified with calcium and vitamin D have a favorable effect on bone mineral density. Combined calcium and vitamin D supplementation could prevent osteoporosis hip fracture in postmenopausal women.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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