Maternal Docosahexaenoic Acid Status during Pregnancy and Its Impact on Infant Neurodevelopment
Basak S, Mallick R, Duttaroy AK
Nutrients · 87 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-11-25 · Nutrients · vol. 12 · número 12 · pág. 3615
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 135 citas · más que el 98% de estudios similares · 6.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 188 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Birth, Development, and Health · Infant Nutrition and Health
- Palabras clave
- Docosahexaenoic acid, Biology, Polyunsaturated fatty acid, Endocrinology, Placentation, Fetus, Internal medicine, Pregnancy, Neuroscience, Biochemistry, Fatty acid, Placenta, Medicine
- MeSH
- milk, human, humans, lutein, docosahexaenoic acids, micronutrients, double-blind method, child development, breast feeding, adult, infant, female, maternal nutritional physiological phenomena, young adult, biomarkers
3 autores
- Sanjay Basak🇮🇳Indian Council of Medical Research
- Rahul Dev Mallick🇫🇮University of Eastern Finland
- Asim K. Duttaroy🇳🇴 · autor de correspondenciaUniversity of Oslo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary components are essential for the structural and functional development of the brain. Among these, docosahexaenoic acid, 22:6n-3 (DHA), is critically necessary for the structure and development of the growing fetal brain in utero. DHA is the major n-3 long-chain polyunsaturated fatty acid in brain gray matter representing about 15% of all fatty acids in the human frontal cortex. DHA affects neurogenesis, neurotransmitter, synaptic plasticity and transmission, and signal transduction in the brain. Data from human and animal studies suggest that adequate levels of DHA in neural membranes are required for maturation of cortical astrocyte, neurovascular coupling, and glucose uptake and metabolism. Besides, some metabolites of DHA protect from oxidative tissue injury and stress in the brain. A low DHA level in the brain results in behavioral changes and is associated with learning difficulties and dementia. In humans, the third trimester-placental supply of maternal DHA to the growing fetus is critically important as the growing brain obligatory requires DHA during this window period. Besides, DHA is also involved in the early placentation process, essential for placental development. This underscores the importance of maternal intake of DHA for the structural and functional development of the brain. This review describes DHA's multiple roles during gestation, lactation, and the consequences of its lower intake during pregnancy and postnatally on the 2019 brain development and function.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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