Ensayo controlado aleatorizado2020

Metabolic Syndrome Features and Excess Weight Were Inversely Associated with Nut Consumption after 1-Year Follow-Up in the PREDIMED-Plus Study

Julibert A, Del Mar Bibiloni M, Gallardo-Alfaro L, Abbate M, Martínez-González MÁ, Salas-Salvadó J, Corella D, Fitó M, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, Lopez-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem L, Cano-Ibañez N, Martín-Sánchez V, Pintó X, Gaforio JJ, Matía-Martín P, Vidal J, Vázquez C, Daimiel L, Ros E, Sayon-Orea C, Becerra-Tomás N, Gimenez-Alba IM, Castañer O, Abete I, Tojal-Sierra L, Pérez-López J, Notario-Barandiaran L, Colom A, Garcia-Rios A, Castro-Barquero S, Bernal R, Santos-Lozano JM, Fernández-Lázaro CI, Hernández-Alonso P, Saiz C, Zomeño MD, Zulet MA, Belló-Mora MC, Basterra-Gortari J, Canudas S, Goday A, Tur JA, PREDIMED-PLUS investigators

The Journal of nutrition · 22 citas

Cómo se estudió

Diseño: Ensayo controlado aleatorizado (indexado por PubMed)
Estudiado en: Personas
Resultado principal: Marcadores de salud y funcionamiento
Consumo medido con: Cuestionario de frecuencia de consumo

Quién lo pagó

Financiación: Financiación independiente
Gobierno: Generalitat Valenciana
Universidad u hospital: Universitat de les Illes Balears
Gobierno: Consejería de Salud y Familias, Junta de Andalucía
Gobierno: Instituto de Salud Carlos III
Gobierno: European Regional Development Fund
Gobierno: H2020 European Research Council
Gobierno: European Research Council
Gobierno: Consejería de Salud, Junta de Andalucía
Gobierno: Spanish government
Universidad u hospital: University of the Balearic Islands
Gobierno: European Commission fund
Subvenciones: European Regional Development Fund (PI14/00636); European Regional Development Fund (PI19/00957); European Regional Development Fund (PI14/00853); European Regional Development Fund (PI19/00017); European Regional Development Fund (PI14/00972); European Regional Development Fund (PI17/01732); European Regional Development Fund (PI14-00696); European Regional Development Fund (PI16/00662); European Regional Development Fund (PI16/01522); European Regional Development Fund (PI17/00855); European Regional Development Fund (PI16/00381); European Regional Development Fund (PI14/01374); Consejería de Salud y Familias, Junta de Andalucía (PI0458/2013); European Regional Development Fund (PI13/00728); Generalitat Valenciana (PROMETEO 2017/017); European Regional Development Fund (PI13/01090); European Regional Development Fund (PI14/01919); European Regional Development Fund (PI17/00525); European Regional Development Fund (PI17/01183); European Regional Development Fund (PI14/00728); European Regional Development Fund (PI14/00618); European Regional Development Fund (PI19/00576); Consejería de Salud y Familias, Junta de Andalucía (PI0137/2018); European Regional Development Fund (CB12/03); European Regional Development Fund (PI14/01206); European Regional Development Fund (PI17/01441); European Regional Development Fund (PI13/00233); European Regional Development Fund (PI19/01332); European Regional Development Fund (PI17/00215); European Regional Development Fund (CB06/03); European Regional Development Fund (PI13/02184); European Regional Development Fund (PI16/00473); European Regional Development Fund (PI13/01123); European Regional Development Fund (PI13/00272); European Regional Development Fund (PI17/00532); European Regional Development Fund (PI19/00781); European Regional Development Fund (PI14/01471); European Regional Development Fund (PI19/01226); European Regional Development Fund (PI16/01094); European Regional Development Fund (PI16/00501); European Regional Development Fund (P I13/00673); European Regional Development Fund (PI17/00926); European Regional Development Fund (PI13/00492); European Regional Development Fund (PI19/00309); European Regional Development Fund (PI19/00386); European Regional Development Fund (PI17/01347); European Regional Development Fund (PI16/00533); European Regional Development Fund (PI17/00764); European Regional Development Fund (PI17/01827); European Regional Development Fund (PI16/01873); Consejería de Salud y Familias, Junta de Andalucía (PS0358/2016); European Regional Development Fund (PI16/00366); European Regional Development Fund (PI16/01120); European Regional Development Fund (PI13/00462); European Regional Development Fund (PI19/01032); European Regional Development Fund (PI19/01560); European Regional Development Fund (PI13/01056); European Regional Development Fund (PI17/00508); European Regional Development Fund (PI14/01722)

Según 11 financiadores declarados.

Publicación

Publicado: 2020-09-02 · J Nutr · vol. 150 · número 12 · págs. 3161–3170
Editorial: Elsevier BV
Citado: 28 citas · más que el 90% de estudios similares · 2.6× el promedio de su campo
Impacto: Entre el 10 % más citado de su campo
Referencias: 44 trabajos
Acceso: Lectura gratuita
Áreas de investigación: Nuts composition and effects · Nutritional Studies and Diet · Nutrition, Genetics, and Disease
Palabras clave: nut consumption, metabolic syndrome, overweight, overweight and obesity, waist circumference, triglycerides, HDL cholesterol, blood pressure, Mediterranean diet, PREDIMED-Plus trial, energy intake, extra virgin olive oil, dietary adherence, middle-aged and older adults
MeSH: humans, nuts, diet, risk factors, cohort studies, follow-up studies, aged, middle aged, female, male, overweight, metabolic syndrome

DOI ↗OpenAlex ↗

50 autores

Alicia Julibert🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Health Research Institute of the Balearic Islands; Universitat de les Illes Balears
María del Mar Bibiloni🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Health Research Institute of the Balearic Islands; Universitat de les Illes Balears
Laura Gallardo-Alfaro🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Health Research Institute of the Balearic Islands; Universitat de les Illes Balears
Manuela Abbate🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Health Research Institute of the Balearic Islands; Universitat de les Illes Balears
Miguel Ángel Martínez‐González🇺🇸🇪🇸Harvard University; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Universidad de Navarra
Jordi Salas‐Salvadó🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Institut de Recerca Biomèdica Catalunya Sud; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
Dolores Corella🇪🇸Universitat de València; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
Montserrat Fitó🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Del Mar; Municipal Institute for Medical Research; Hospital del Mar Research Institute
José Alfredo Martínez🇪🇸Madrid Institute for Advanced Studies; Consejo Superior de Investigaciones Científicas; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; IMDEA Food; Universidad Autónoma de Madrid; Universidad de Navarra
Ángel M. Alonso‐Gómez🇪🇸University of the Basque Country; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Universitario Araba
Julia Wärnberǵ🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Instituto de Investigación Biomédica de Málaga; Universidad de Málaga
Jesús Vioqué🇪🇸Universitat de Miguel Hernández d'Elx; Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL)
Dora Romaguera🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Health Research Institute of the Balearic Islands
José López‐Miranda🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Instituto Maimónides de Investigación Biomédica de Córdoba; University of Córdoba
Ramón Estruch🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer; Universitat de Barcelona
Francisco José Tinahones🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Clínico Universitario Virgen de la Victoria; Universidad de Málaga
José Lapetra🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
Lluís Serra‐Majem🇪🇸Universidad de Las Palmas de Gran Canaria; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
Naomi Cano Ibáñez🇪🇸Universidad de Granada; Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Vicente Martín🇪🇸Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas; Centro de Investigación Biomédica en Red; Universidad de León
Xavier Pintó🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Bellvitge University Hospital
José Juan Gaforio🇪🇸Universidad de Jaén; Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Pilar Matía‐Martín🇪🇸Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
Josép Vidal🇪🇸Consorci Institut D'Investigacions Biomediques August Pi I Sunyer; Universitat de Barcelona
Clotilde Vázquez🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Universitario Fundación Jiménez Díaz
Lidia Daimiel🇪🇸Madrid Institute for Advanced Studies; IMDEA Food; Universidad Autónoma de Madrid
Emilio Ros🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer; Universitat de Barcelona
Carmen Sayón-Orea🇪🇸Servicio Navarro de Salud; Navarre Institute of Health Research; Universidad de Navarra
Nerea Becerra‐Tomás🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Institut de Recerca Biomèdica Catalunya Sud; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
Ignacio Manuel Gimenez-Alba🇪🇸Universitat de València; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
Olga Castañer🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Del Mar; Municipal Institute for Medical Research; Hospital del Mar Research Institute
Itziar Abete🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Universidad de Navarra
Lucas Tojal‐Sierra🇪🇸University of the Basque Country; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Universitario Araba
Jessica Pérez‐López🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Instituto de Investigación Biomédica de Málaga; Universidad de Málaga
Leyre Notario-Barandiarán🇪🇸Universitat de Miguel Hernández d'Elx; Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL)
Antoni Colom🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Health Research Institute of the Balearic Islands
Antonio Garcia-Rios🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Instituto Maimónides de Investigación Biomédica de Córdoba; University of Córdoba
Sara Castro‐Barquero🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer; Universitat de Barcelona
Rosa Bernal🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Clínico Universitario Virgen de la Victoria; Universidad de Málaga
José Manuel Santos‐Lozano🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
Cesar Ignacio Fernandez-Lazaro🇪🇸Navarre Institute of Health Research; Universidad de Navarra
Pablo Hernández‐Alonso🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Institut de Recerca Biomèdica Catalunya Sud; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
Carmen Sáiz🇪🇸Universitat de València; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
María Dolores Zomeño🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Del Mar; Municipal Institute for Medical Research; Hospital del Mar Research Institute
M. Ángeles Zulet🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Universidad de Navarra
María C. Belló-Mora🇪🇸University of the Basque Country; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Universitario Araba
Javier Basterra-Gortari🇪🇸Servicio Navarro de Salud; Navarre Institute of Health Research; Universidad de Navarra
Sı́lvia Canudas🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Institut de Recerca Biomèdica Catalunya Sud; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
Albert Goday🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Del Mar; Municipal Institute for Medical Research; Hospital del Mar Research Institute
Josep Antoni Tur🇪🇸 · autor de correspondenciaInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Health Research Institute of the Balearic Islands; Universitat de les Illes Balears

Resumen

El texto original del estudio, en el idioma en que se publicó.

Background

High nut consumption has been previously associated with decreased prevalence of metabolic syndrome (MetS) regardless of race and dietary patterns.

Objectives

The aim of this study was to assess whether changes in nut consumption over a 1-y follow-up are associated with changes in features of MetS in a middle-aged and older Spanish population at high cardiovascular disease risk.

Methods

This prospective 1-y follow-up cohort study, conducted in the framework of the PREvención con DIeta MEDiterránea (PREDIMED)-Plus randomized trial, included 5800 men and women (55-75 y old) with overweight/obesity [BMI (in kg/m2) ≥27 and <40] and MetS. Nut consumption (almonds, pistachios, walnuts, and other nuts) was assessed using data from a validated FFQ. The primary outcome was the change from baseline to 1 y in features of MetS [waist circumference (WC), glycemia, HDL cholesterol, triglyceride (TG), and systolic and diastolic blood pressure] and excess weight (body weight and BMI) according to tertiles of change in nut consumption. Secondary outcomes included changes in dietary and lifestyle characteristics. A generalized linear model was used to compare 1-y changes in features of MetS, weight, dietary intakes, and lifestyle characteristics across tertiles of change in nut consumption.

Results

As nut consumption increased, between each tertile there was a significant decrease in WC, TG, systolic blood pressure, weight, and BMI (P < 0.05), and a significant increase in HDL cholesterol (only in women, P = 0.044). The interaction effect between time and group was significant for total energy intake (P < 0.001), adherence to the Mediterranean diet (MedDiet) (P < 0.001), and nut consumption (P < 0.001). Across tertiles of increasing nut consumption there was a significant increase in extra virgin olive oil intake and adherence to the MedDiet; change in energy intake, on the other hand, was inversely related to consumption of nuts.

Conclusions

Features of MetS and excess weight were inversely associated with nut consumption after a 1-y follow-up in the PREDIMED-Plus study cohort. This trial was registered at isrctn.com as ISRCTN89898870.

Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.

Leer el texto completo ↗Ver en PubMed ↗

Confianza de la comunidad

Cargando…

¿Cuánto confías en los hallazgos de este estudio?

0 · nada10 · totalmente

Comentarios

¿Algo está mal aquí?

Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.

Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.