Financiado en parte por U.S. Highbush Blueberry Council
Blueberry phenolics are associated with cognitive enhancement in supplemented healthy older adults
Rutledge GA, Sandhu AK, Miller MG, Edirisinghe I, Burton-Freeman BB, Shukitt-Hale B
Food & function · 29 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Agriculture
- Grupo de la industria
- U.S. Highbush Blueberry Council
- Gobierno
- National Institutes of Health
- Subvenciones
- National Institutes of Health (T32 AG00002941)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2020-12-15 · Food Funct · vol. 12 · número 1 · págs. 107–118
- Editorial
- Royal Society of Chemistry
- Citado
- 51 citas · más que el 98% de estudios similares · 7.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- De pago
- Áreas de investigación
- Ginkgo biloba and Cashew Applications · Medicinal Plants and Neuroprotection · Phytochemicals and Antioxidant Activities
- Palabras clave
- Cognition, Food science, Cognitive decline, Medicine, Chemistry, Dementia, Internal medicine, Psychiatry
- MeSH
- humans, phenols, nootropic agents, double-blind method, cognition, dietary supplements, aged, middle aged, female, male, blueberry plants
6 autores
- Grant A. Rutledge🇺🇸Tufts University; Agricultural Research Service
- Amandeep Kaur Sandhu🇺🇸Illinois Institute of Technology
- Marshall G. Miller🇺🇸Tufts University; Agricultural Research Service
- Indika Edirisinghe🇺🇸Illinois Institute of Technology
- Britt Marie Burton‐Freeman🇺🇸Illinois Institute of Technology
- Barbara Shukitt‐Hale🇺🇸 · autor de correspondenciaTufts University; Agricultural Research Service
Resumen
El texto original del estudio, en el idioma en que se publicó.
Blueberries (BB) contain an array of bioactive phenolic compounds that may play a protective role against various age-related diseases. Here we explored the metabolic fate of BB phenolics and their relationship to cognitive function after chronic (90 days) supplementation of freeze-dried BB (24 g d-1, equivalent to 1 cup of fresh BB) or control in a randomized, double-blind, parallel study with 38 healthy older adults (60-75 years). Blood samples were collected at fasting (t = 0 h) and 2 h after a breakfast meal on days 0 (no treatment), 45, and 90, and a battery of cognitive tests was also conducted on these days. Hippuric acid, phloroglucinaldehyde, syringic acid, ferulic acid-glucuronide, cyanidin-3-O-galactoside, cyanidin-3-O-glucoside, malvidin-3-O-galactoside, malvidin-3-O-glucoside, peonidin-3-O-xyloside, peonidin glucuronide, and petunidin-3-O-glucoside concentrations were significantly altered after 90 days of BB consumption compared to control. Stepwise regression was used to assess the relationship between significantly altered concentrations of plasma phenolics and observed improvements in cognition. Among participants in the BB group, changes in switch errors on the task-switching test (TST) from day 0 to 90 were associated with changes in postprandial levels of plasma ferulic acid-glucuronide, syringic acid, and malvidin-3-galactoside (R2 = 0.521, p 2 = 0.807, p < 0.001). These findings demonstrate that the addition of easily achievable quantities of BB to the diets of older adults significantly alters levels of circulating phenolic compounds which are related to improvements in cognition.
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