Financiado en parte por Malaysian Palm Oil Board
Eucaloric diets enriched in palm olein, cocoa butter, and soybean oil did not differentially affect liver fat concentration in healthy participants: a 16-week randomized controlled trial
Stonehouse W, Sergi D, Benassi-Evans B, James-Martin G, Johnson N, Thompson CH, Abeywardena M
The American journal of clinical nutrition · 13 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Malaysian Palm Oil Board
Según 1 financiador declarado.
Publicación
- Publicado
- 2020-10-28 · Am J Clin Nutr · vol. 113 · número 2 · págs. 324–337
- Editorial
- Elsevier BV
- Citado
- 15 citas · más que el 78% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 54 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Diet, Metabolism, and Disease · Liver Disease Diagnosis and Treatment
- Palabras clave
- liver fat, dietary fat quality, palm olein, cocoa butter, soybean oil, eucaloric diet, visceral adipose tissue, subcutaneous abdominal fat, abdominal fat, serum cholesterol, LDL cholesterol, HDL cholesterol, apolipoproteins, cardiometabolic health, healthy young adults, triacylglycerol composition
- MeSH
- liver, adipose tissue, feces, humans, dietary fats, soybean oil, fatty acids, nonesterified, energy intake, adult, female, male, palm oil
7 autores
- Welma Stonehouse🇦🇺 · autor de correspondenciaCommonwealth Scientific and Industrial Research Organisation
- Domenico Sergi🇦🇺Commonwealth Scientific and Industrial Research Organisation
- Bianca Benassi-Evans🇦🇺Commonwealth Scientific and Industrial Research Organisation
- Genevieve James‐Martin🇦🇺Commonwealth Scientific and Industrial Research Organisation
- Nathan Anthony Johnson🇦🇺The University of Sydney
- Campbell Henry Thompson🇦🇺The University of Adelaide
- Mahinda Yapa Abeywardena🇦🇺Commonwealth Scientific and Industrial Research Organisation
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Effects of dietary fat quality on liver fat remain to be elucidated. Inconsistent evidence may be influenced by fatty acid saturation, chain-length, and regio-specificity within triacylglycerol (TAG) molecules.
Objectives
We aimed to compare eucaloric diets enriched in palm olein (POo), cocoa butter (COB), and soybean oil (SBO) on liver fat concentration in healthy participants. Secondary outcomes included visceral (VAT) and abdominal subcutaneous (aSCAT) adipose tissue, plus other obesity and cardiometabolic health outcomes.
Methods
Eighty-three healthy participants (20-45 y, BMI 18.5-27.5 kg/m2) commenced and 64 completed a 16-wk randomized parallel intervention, preceded by a 2-wk run-in. Participants consumed identical eucaloric background diets differing in test fats [contributing 20% total energy intake (%E)], providing 33%E total fat with the following ratios for PUFAs/SFAs/MUFAs: POo, 4.2/13.5/15%E; SBO, 14.4/8.8/9.4%E; COB, 2.3/19.5/11%E. Liver fat and abdominal adiposity were measured at weeks 0 and 16 using 1H-magnetic resonance spectroscopy/imaging; all other outcomes were measured at 0, 4, 8, 12, and 16 wk.
Results
Fat quality did not affect liver fat concentration, VAT, aSCAT, obesity indexes, blood pressure, liver enzymes, leptin, or fasting glucose. Body fat mass decreased with SBO and COB compared with POo. SBO decreased serum total cholesterol (TC), LDL cholesterol, and TC:HDL cholesterol relative to POo [estimated marginal mean (95% CI) differences: -0.57 (-0.94, -0.20) mmol/L; -0.37 (-0.68, -0.07) mmol/L; and -0.42 (-0.73, -0.11) mmol/L, respectively]. No diet differences were observed on HDL cholesterol, TAG, apoA1, apoB, apoB:apoA1, or fecal free fatty acids (FFAs), except for lower FFA pentadecanoic acid (15:0) with COB than with SBO and POo.
Conclusions
In healthy adults, when consumed as part of eucaloric typical Australian diets, 3 different dietary fat sources did not differentially affect liver fat concentration and amounts of adipose tissue. Effects on serum lipids were inconsistent across lipid profiles. The findings must be confirmed in metabolically impaired individuals before recommendations can be made.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.