The prebiotic effects of omega-3 fatty acid supplementation: A six-week randomised intervention trial
Vijay A, Astbury S, Le Roy C, Spector TD, Valdes AM
Gut microbes · 99 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Medical Research Council
- Subvenciones
- Medical Research Council (MR/N01183X/1)
Según 1 financiador declarado.
Publicación
- Publicado
- 2020-12-31 · Gut Microbes · vol. 13 · número 1 · págs. 1–11
- Editorial
- Landes Bioscience
- Citado
- 122 citas · más que el 96% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Gut microbiota and health · Fatty Acid Research and Health · Microbial Metabolites in Food Biotechnology
- Palabras clave
- omega-3 fatty acids, prebiotics, inulin, gut microbiota, dietary supplementation, short-chain fatty acids, butyrate, isovalerate, Coprococcus, Bacteroides, Collinsella, VLDL triglycerides, Bifidobacterium, Lachnospiraceae, cardiovascular health
- MeSH
- humans, bacteria, inulin, lipids, fatty acids, omega-3, fatty acids, body mass index, dietary supplements, aged, middle aged, female, male, prebiotics, gastrointestinal microbiome
5 autores
- Amrita Vijay🇬🇧 · autor de correspondenciaUniversity of Nottingham; King's College London
- Stuart Astbury🇬🇧Nottingham University Hospitals NHS Trust; University of Nottingham; Nottingham Biomedical Research Centre
- Caroline Ivanne Le Roy🇬🇧King's College London
- Tim D. Spector🇬🇧King's College London
- Ana Maria Valdes🇬🇧Nottingham University Hospitals NHS Trust; University of Nottingham; King's College London; Nottingham Biomedical Research Centre
Resumen
El texto original del estudio, en el idioma en que se publicó.
Prebiotics are compounds in food that benefit health via affecting the gut microbiome. Omega-3 fatty acids have been associated with differences in gut microbiome composition and are widely accepted to have health benefits, although recent large trials have been inconclusive. We carried out a 6-week dietary intervention comparing the effects of daily supplementation with 500 mg of omega-3 versus 20 g of a well-characterized prebiotic, inulin. Inulin supplementation resulted in large increases in Bifidobacterium and Lachnospiraceae. In contrast, omega-3 supplementation resulted in significant increases in Coprococcus spp. and Bacteroides spp, and significant decreases in the fatty-liver associated Collinsella spp. On the other hand, similar to the results with inulin supplementation which resulted in significant increases in butyrate, iso-valerate, and iso-butyrate (p p p Coprococcus, which was significantly increased post-supplementation with omega-3, was found to be positively associated with iso-butyric acid (Beta (SE) = 0.69 (0.02), P = 1.4 x 10-3) and negatively associated with triglyceride-rich lipoproteins such as VLDL (Beta (SE) = -0.381 (0.01), P = .001) and VLDL-TG (Beta (SE) = -0.372 (0.04), P = .001) after adjusting for confounders. Dietary omega-3 alters gut microbiome composition and some of its cardiovascular effects appear to be potentially mediated by its effect on gut microbial fermentation products indicating that it may be a prebiotic nutrient.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.