Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis
Liu N, Sun J, Wang X, Zhang T, Zhao M, Li H
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 107 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Science and Technology Major Project
- Gobierno
- National Key Research and Development Program of China
- Gobierno
- National Major Science and Technology Projects of China
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-01-02 · Int J Infect Dis · vol. 104 · págs. 58–64
- Editorial
- Elsevier BV
- Citado
- 194 citas · más que el 99% de estudios similares · 11.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Vitamin D Research Studies · COVID-19 Clinical Research Studies · SARS-CoV-2 and COVID-19 Research
- Palabras clave
- vitamin D deficiency, vitamin D insufficiency, COVID-19 pandemic, SARS-CoV-2 infection risk, vitamin D status, vitamin D supplementation, clinical prognosis
- MeSH
- humans, vitamin d deficiency, vitamin d, dietary supplements, covid-19, sars-cov-2
6 autores
- Nanyang Liu🇨🇳Xiyuan Hospital; China Academy of Chinese Medical Sciences
- Jiahui Sun🇨🇳Beijing University of Chinese Medicine
- Xiyuan Wang🇨🇳Beijing University of Chinese Medicine
- Tingting Zhang🇨🇳Shandong University of Traditional Chinese Medicine
- Ming Zhao🇨🇳Beijing University of Chinese Medicine
- Hao Li🇨🇳 · autor de correspondenciaXiyuan Hospital; China Academy of Chinese Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Observational studies suggest that the risk and clinical prognosis of coronavirus disease 2019 (COVID-19) are related to low vitamin D status; however, the data are inconsistent.
Objectives
We conducted a systematic review and meta-analysis to assess the association between low vitamin D status and COVID-19.
Methods
A systematic search was conducted with PubMed, Embase, and the Cochrane Library from database inception to September 25, 2020. The standardized mean difference (SMD) or odds ratio (OR) and corresponding 95% confidence interval (CI) was applied to estimate pooled results. Random - or fixed-effect models based on heterogeneity were used for the meta-analysis. Funnel plots and Egger regression tests were used to assess publication bias.
Results
A total of ten articles with 361,934 participants were selected for meta-analysis. Overall, the pooled OR in the fixed-effect model showed that vitamin D deficiency or insufficiency was associated with an increased risk of COVID-19 (OR = 1.43, 95% CI 1.00-2.05). In addition, COVID-19-positive individuals had lower vitamin D levels than COVID-19-negative individuals (SMD = -0.37, 95% CI = -0.52 to -0.21). Significant heterogeneity existed in both endpoints. Funnel plots and Egger regression tests revealed significant publication bias.
Conclusions
This systematic review and meta-analysis indicated that low vitamin D status might be associated with an increased risk of COVID-19 infection. Further studies are needed to evaluate the impact of vitamin D supplementation on the clinical severity and prognosis in patients with COVID-19.
Systematic review registration
PROSPERO registration no: CRD42020216740.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.