Timing of acute passive heating on glucose tolerance and blood pressure in people with type 2 diabetes: a randomized, balanced crossover, control trial
James TJ, Corbett J, Cummings M, Allard S, Young JS, Towse J, Carey-Jones K, Eglin C, Hopkins B, Morgan C, Tipton M, Tipton M, Saynor ZL, Shepherd AI
Journal of applied physiology (Bethesda, Md. : 1985) · 14 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Portsmouth
Según 1 financiador declarado.
Publicación
- Publicado
- 2021-01-07 · J Appl Physiol (1985) · vol. 130 · número 4 · págs. 1093–1105
- Editorial
- American Physiological Society
- Citado
- 19 citas · más que el 82% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 86 trabajos
- Acceso
- De pago
- Áreas de investigación
- Thermoregulation and physiological responses · Adipose Tissue and Metabolism · Exercise and Physiological Responses
- Palabras clave
- Crossover study, Blood pressure, Ingestion, Medicine, Diabetes mellitus, Type 2 diabetes, Internal medicine, Heart rate, Endocrinology, Cardiology, Placebo
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, insulin, glucose, blood glucose, heating, blood pressure
13 autores
- Thomas J. James🇬🇧Portsmouth Hospitals NHS Trust; University of Portsmouth
- Jo Corbett🇬🇧University of Portsmouth
- Michael Cummings🇬🇧Portsmouth Hospitals NHS Trust
- Sharon Allard🇬🇧Portsmouth Hospitals NHS Trust
- John S. Young🇬🇧University of Portsmouth
- Jonathan Towse🇬🇧University of Portsmouth
- Kathryn Carey-Jones🇬🇧Oaks Hospital; University of Portsmouth
- Clare Eglin🇬🇧University of Portsmouth
- Billy Hopkins🇬🇧University of Portsmouth
- Connor Morgan🇬🇧University of Portsmouth
- Mike Tipton🇬🇧University of Portsmouth
- ZOE LOUISE SAYNOR🇬🇧Portsmouth Hospitals NHS Trust; University of Portsmouth
- Anthony I. Shepherd🇬🇧 · autor de correspondenciaPortsmouth Hospitals NHS Trust; University of Portsmouth
Resumen
El texto original del estudio, en el idioma en que se publicó.
Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia and progressive insulin resistance, leading to macro and microvascular dysfunction. Passive heating has potential to improve glucose homeostasis and act as an exercise mimetic. We assessed the effect of acute passive heating before or during an oral glucose tolerance test (OGTT) in people with T2DM. Twelve people with T2DM were randomly assigned to the following three conditions: 1) 3-h OGTT (control), 2) 1-h passive heating (40°C water) 30 min before an OGTT (HOT-OGTT), and 3) 1-h passive heating (40°C water) 30 min after commencing an OGTT (OGTT-HOT). Blood glucose concentration, insulin sensitivity, extracellular heat shock protein 70 (eHSP70), total energy expenditure (TEE), heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were recorded. Passive heating did not alter blood glucose concentration [control: 1,677 (386) arbitrary units (AU), HOT-OGTT: 1,797 (340) AU, and OGTT-HOT: 1,662 (364) AU, P = 0.28], insulin sensitivity (P = 0.15), or SBP (P = 0.18) but did increase eHSP70 concentration in both heating conditions [control: 203.48 (110.81) pg·mL-1; HOT-OGTT: 402.47 (79.02) pg·mL-1; and OGTT-HOT: 310.00 (60.53) pg·mL-1, P P = 0.001], increased HR in both heating conditions (P P NEW & NOTEWORTHY This is the first study to investigate the timing of acute passive heating on glucose tolerance and extracellular heat shock protein 70 concentration ([eHSP70]) in people with type 2 diabetes. The principal novel findings from this study were that both passive heating conditions: 1) did not reduce the area under the curve or peak blood glucose concentration, 2) elevated heart rate, and 3) increased [eHSP70], which was blunted by glucose ingestion, while passive heating following glucose ingestion, 4) increased total energy expenditure, and 5) reduced diastolic blood pressure.
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