Epigenetic Modifications Induced by Olive Oil and Its Phenolic Compounds: A Systematic Review
Fabiani R, Vella N, Rosignoli P
Molecules (Basel, Switzerland) · 34 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Università degli Studi di Perugia
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-01-07 · Molecules · vol. 26 · número 2 · pág. 273
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 48 citas · más que el 44% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 76 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Edible Oils Quality and Analysis · Fatty Acid Research and Health · Sesame and Sesamin Research
- Palabras clave
- Olive oil, Epigenetics, Chemistry, Food science, Biochemistry, Gene
- MeSH
- humans, olea, phenols, histones, micrornas, anti-inflammatory agents, dna methylation, epigenesis, genetic, gene expression regulation, plant, olive oil
3 autores
- Roberto Fabiani🇮🇹 · autor de correspondenciaUniversity of Perugia
- Nicolò Vella🇮🇹University of Perugia
- Patrizia Rosignoli🇮🇹University of Perugia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Many studies demonstrated that olive oil (especially extra virgin olive oil: EVOO) phenolic compounds are bioactive molecules with anti-cancer, anti-inflammatory, anti-aging and neuroprotective activities. These effects have been recently attributed to the ability of these compounds to induce epigenetics modifications such as miRNAs expression, DNA methylation and histone modifications. In this study, we systematically review and discuss, following the PRISMA statements, the epigenetic modifications induced by EVOO and its phenols in different experimental systems. At the end of literature search through "PubMed", "Web of Science" and "Scopus", 43 studies were selected.Among them, 22 studies reported data on miRNAs, 15 on DNA methylation and 13 on histone modification. Most of the "epigenomic" changes observed in response to olive oil phenols' exposure were mechanistically associated with the cancer preventive and anti-inflammatory effects. In many cases, the epigenetics effects regarding the DNA methylation were demonstrated for olive oil but without any indication regarding the presence or not of phenols. Overall, the findings of the present systematic review may have important implications for understanding the epigenetic mechanisms behind the health effects of olive oil. However, generally no direct evidence was provided for the causal relationships between epigenetics modification and EVOO health related effects. Further studies are necessary to demonstrate the real physiological consequences of the epigenetics modification induced by EVOO and its phenolic compounds.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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