TCF7L2 polymorphisms, nut consumption, and the risk of metabolic syndrome: a prospective population based study
Hosseinpour-Niazi S, Bakhshi B, Zahedi AS, Akbarzadeh M, Daneshpour MS, Mirmiran P, Azizi F
Nutrition & metabolism · 6 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Shahid Beheshti University of Medical Sciences
- Universidad u hospital
- Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences
- Subvenciones
- Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences (18360)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-01-12 · Nutr Metab (Lond) · vol. 18 · número 1 · pág. 10
- Editorial
- BioMed Central
- Citado
- 12 citas · más que el 72% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 51 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Oral Health Pathology and Treatment
- Palabras clave
- Medicine, Confounding, Metabolic syndrome, Hazard ratio, Internal medicine, Interquartile range, Prospective cohort study, Odds ratio, Weight gain, Population, Nut, Lower risk, Obesity, Confidence interval, Environmental health, Body weight
7 autores
- Somayeh Hosseinpour‐Niazi🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Bahar Bakhshi🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Asiyeh Sadat Zahedi🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Mahdi Akbarzadeh🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- MARYAM SADAT DANESHPOUR🇮🇷 · autor de correspondenciaResearch Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Parvin Mirmiran🇮🇷 · autor de correspondenciaNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Fereidoun Azizi🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The aim of this study was to investigate whether two variants of the TCF7L2 (rs7903146 and rs12255372) modify the association between nut consumption and the risk of metabolic syndrome (MetS). Additionally, the modifying effect of weight change during follow-up on these associations was investigated.
Material and methods
We prospectively studied 1423 participants of the Tehran Lipid and Glucose study aged 19-74 years who were followed-up for dietary assessment using a validated, semi-quantitative food frequency questionnaire. Multivariable-adjusted Cox regression was used to estimate hazard ratios (HRs) for MetS events. Genotyping was performed by Human Omni Express-24-v1-0 chip.
Results
Over a median 8.9 years of follow-up, 415 new cases of MetS were documented. The median nut consumption was 20.0 g/week (Interquartile Range (IQR): 8.6-38.9 g/week). Regarding the rs7903146 genotype, in carriers of T allele (CT + TT), highest tertile of nut consumption was associated with a reduced risk of MetS after adjusting for confounders (HR: 0.67 (0.50-0.91)). Regarding the rs12255372 genotype, highest versus lowest tertile of nut consumption in participants with T allele (GT + TT) resulted in 34% reduction of MetS risk after adjustment for confounders (HR: 0.66 (0.49-0.69)). After stratification by weigh change (< 7% or ≥ 7% weight gain), in individuals with ≥ 7% weight gain, highest tertile of nut consumption was associated with reduced risk of MetS among the risk allele of rs7903146. In the risk allele of rs12255372, among individuals with < 7% weight gain, third tertile of nuts intake reduced the risk of MetS, after adjustment for confounders.
Conclusion
Higher consumption of nuts may reduces the risk of MetS in T-risk allele of the TCF7L2 rs7903146 and rs12255372 variants and weight change may modify this association.
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