Financiado en parte por Almond Board of California
Almond consumption affects fecal microbiota composition, stool pH, and stool moisture in overweight and obese adults with elevated fasting blood glucose: A randomized controlled trial
Choo JM, Tran CD, Luscombe-Marsh ND, Stonehouse W, Bowen J, Johnson N, Thompson CH, Watson EJ, Brinkworth GD, Rogers GB
Nutrition research (New York, N.Y.) · 28 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Almond Board of California
Según 1 financiador declarado.
Publicación
- Publicado
- 2020-11-20 · Nutr Res · vol. 85 · págs. 47–59
- Editorial
- Elsevier BV
- Citado
- 37 citas · más que el 77% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 64 trabajos
- Acceso
- De pago
- Áreas de investigación
- Gut microbiota and health · Nuts composition and effects · Nutritional Studies and Diet
- Palabras clave
- almond consumption, fecal microbiota, gut microbiota composition, overweight, obesity, Ruminococcaceae, Ruminiclostridium, short-chain fatty acids, butyrate production, intestinal permeability, fecal pH, fecal moisture, dietary intervention
- MeSH
- feces, humans, bacteria, nuts, obesity, blood glucose, fatty acids, volatile, eating, hydrogen-ion concentration, middle aged, female, male, overweight, gastrointestinal microbiome, prunus dulcis, bacillota
10 autores
- Jocelyn M. Choo🇦🇺 · autor de correspondenciaFlinders University; South Australian Health and Medical Research Institute
- Cuong Duy Tran🇦🇺Commonwealth Scientific and Industrial Research Organisation
- Natalie D. Luscombe‐Marsh🇦🇺Commonwealth Scientific and Industrial Research Organisation
- Welma Stonehouse🇦🇺Commonwealth Scientific and Industrial Research Organisation
- Jane Bowen🇦🇺Commonwealth Scientific and Industrial Research Organisation
- Nathan Anthony Johnson🇦🇺The University of Sydney
- Campbell Henry Thompson🇦🇺The University of Adelaide
- Emma-Jane Watson🇦🇺Commonwealth Scientific and Industrial Research Organisation
- Grant David Brinkworth🇦🇺Commonwealth Scientific and Industrial Research Organisation; CSIRO Health and Biosecurity
- Geraint B. Rogers🇦🇺Flinders University; South Australian Health and Medical Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Regular almond consumption has been shown to improve body weight management, lipid profile and blood glucose control. We hypothesized that almond consumption would alter fecal microbiota composition, including increased abundance and activity of potentially beneficial bacterial taxa in adults who are overweight and obese with elevated fasting blood glucose. A total of 69 adults who were overweight or obese with an elevated plasma glucose (age: 60.8 ± 7.4, BMI ≥27 kg/m2, fasting plasma glucose ≥5.6 to <7.0 mmol/L) were randomized to daily consumption of either 2 servings of almonds (AS:56 g/day) or an isocaloric, high carbohydrate biscuit snack for 8 weeks. AS but not biscuit snack experienced significant changes in microbiota composition (P= .011) and increases in bacterial richness, evenness, and diversity (P< .01). Increases in both the relative and absolute abundance of operational taxonomic units in the Ruminococcaceae family, including Ruminiclostridium (false discovery rate P = .002), Ruminococcaceae NK4A214 (P = .002) and Ruminococcaceae UCG-003 (P = .002) were the principal drivers of microbiota-level changes. No changes in fecal short chain fatty acid levels, or in the carriage of the gene encoding butyryl-CoA:acetate CoA-transferase (an enzyme involved in butyrate synthesis) occurred. Almond consumption was not associated with reduced gut permeability, but fecal pH (P= .0006) and moisture content (P = .027) decreased significantly in AS when compared to BS. Regular almond consumption increased the abundance of potentially beneficial ruminococci in the fecal microbiota in individuals with elevated blood glucose. However, fecal short-chain fatty acid levels remained unaltered and the capacity for such microbiological effects to precipitate host benefit is not known.
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