Financiado en parte por JC USA, Inc.
Effect of time restricted eating on body weight and fasting glucose in participants with obesity: results of a randomized, controlled, virtual clinical trial
Peeke PM, Greenway FL, Billes SK, Zhang D, Fujioka K
Nutrition & diabetes · 110 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Health and Human Services
- Universidad u hospital
- Louisiana Clinical and Translational Science Center
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of General Medical Sciences
- Gobierno
- U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)
- Empresa
- JC USA, Inc.
- Gobierno
- U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences
- Gobierno
- NIGMS NIH HHS
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Institute of General Medical Sciences (U54‐ GM104940); Louisiana Clinical and Translational Science Center (U54GM104940); U.S. Department of Health and Human Services (1 U54 GM104940); National Institute of General Medical Sciences (GM104940); Louisiana Clinical and Translational Science Center (1 U54 GM104940); Louisiana Clinical and Translational Science Center (GM104940); National Institutes of Health (3u54gm104940-06s1); National Institutes of Health (U54‐GM104940); National Institutes of Health (1U54‐GM‐104940); National Institutes of Health (GM104940); National Institute of General Medical Sciences (1 U54 GM104940)
Según 8 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-01-15 · Nutr Diabetes · vol. 11 · número 1 · pág. 6
- Editorial
- Springer Nature
- Citado
- 138 citas · más que el 99% de estudios similares · 11.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Enhanced Recovery After Surgery · Diet and metabolism studies
- Palabras clave
- Obesity, Randomized controlled trial, Medicine, Body weight, Physical therapy, Psychology, Gerontology, Internal medicine
- MeSH
- humans, obesity, body weight, glucose, blood glucose, body mass index, treatment outcome, exercise, diet, reducing, diet, fasting, pilot projects, energy intake, adult, middle aged, female, male, weight reduction programs, meals, snacks
5 autores
- Pamela M. Peeke🇺🇸 · autor de correspondenciaUniversity of Maryland, Baltimore; University of Maryland Extension
- Frank L. Greenway🇺🇸Pennington Biomedical Research Center
- Sonja K. Billes
- Dachuan Zhang🇺🇸Pennington Biomedical Research Center
- Ken Fujioka🇺🇸Scripps Clinic
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Time restricted eating (TRE) is an emerging dietary intervention for weight loss that is hypothesized to reinforce the metabolic benefits of nightly fasting/ketosis. This pilot study investigated the effectiveness of a daily 14-h metabolic fast (14:10 TRE beginning after dinner, a "fasting snack" at hour 12, and ending with breakfast 14 h later) combined with a commercial weight management program on body weight and fasting blood glucose (FBG) in individuals with obesity. We also investigated the effect of the low-calorie, high-fat, low-carbohydrate, and low-protein "fasting snack" on blood glucose.
Methods
This 8-week, randomized, controlled, clinical trial included men and women (BMI ≥ 30 kg/m2) between June and October 2020. Study procedures were conducted remotely. Participants were randomized to 14:10 or 12-h TRE (12:12, active comparator) and prescribed a diet (controlled for calories and macronutrient composition) and exercise program that included weekly customized counseling and support. The primary outcome was change from baseline in body weight in the 14:10 group.
Results
Of the 78 randomized participants, 60 (n = 30/group) completed 8 weeks. The LS mean change from baseline in weight in the 14:10 group was -8.5% (95% CI -9.6 to -7.4; P < 0.001) and -7.1% (-8.3 to -5.8; P < 0.001) in the 12:12 group (between group difference -1.4%; -2.7 to -0.2; P < 0.05). There was a statistically significant LS mean change from baseline to week 8 in FBG in the 14:10 group of -7.6 mg/dl (95% CI -15.1 to -0.1; P < 0.05) but not in the 12:12 group (-3.1 mg/dl, -10.0 to 3.7; P = NS). Both interventions resulted in a larger reduction in FBG in participants with elevated FBG (≥100 mg/dl) at baseline (both P < 0.05).
Conclusions
In participants with obesity who completed 8 weeks of the 14:10 TRE schedule combined with a commercial weight loss program, there was statistically significant and clinically meaningful weight loss and improvements in FBG.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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