The improvement of cognitive deficits after whole-body cryotherapy - A randomised controlled trial
Rymaszewska J, Lion KM, Stańczykiewicz B, Rymaszewska JE, Trypka E, Pawlik-Sobecka L, Kokot I, Płaczkowska S, Zabłocka A, Szcześniak D
Experimental gerontology · 17 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministerstwo Edukacji i Nauki
- Gobierno
- Ministerstwo Nauki i Szkolnictwa Wyższego
- Subvenciones
- Ministerstwo Edukacji i Nauki (ST.C230.14.079)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2021-01-14 · Exp Gerontol · vol. 146 · pág. 111237
- Editorial
- Elsevier BV
- Citado
- 32 citas · más que el 93% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 96 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Dementia and Cognitive Impairment Research · Thermal Regulation in Medicine · Transcranial Magnetic Stimulation Studies
- Palabras clave
- whole-body cryotherapy, mild cognitive impairment, cognitive function, brain-derived neurotrophic factor, neurotrophins, cytokines, depressive symptoms, quality of life, dementia prevention, early intervention, memory retrieval, orientation
- MeSH
- humans, cryotherapy, prospective studies, cognition, quality of life, australia, cognitive dysfunction
10 autores
- Joanna Rymaszewska🇵🇱Wroclaw Medical University
- Katarzyna Lion🇦🇺🇵🇱 · autor de correspondenciaGriffith University; Wroclaw Medical University
- Bartłomiej Stańczykiewicz🇵🇱Wroclaw Medical University
- Julia Ewa Rymaszewska🇵🇱Wroclaw Medical University
- Elżbieta Trypka🇵🇱Wroclaw Medical University
- Lilla Pawlik-Sobecka🇵🇱Wroclaw Medical University
- Izabela Kokot🇵🇱Wroclaw Medical University
- Sylwia Płaczkowska🇵🇱Wroclaw Medical University
- Agnieszka Zabłocka🇵🇱Ludwik Hirszfeld Institute of Immunology and Experimental Therapy; Polish Academy of Sciences
- Dorota Maria Szcześniak🇵🇱Wroclaw Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Whole-body cryotherapy (WBC) - a repetitive, short-term exposure to extremely low temperatures - may become an effective early intervention for mild cognitive impairment (MCI). It is a heterogeneous group of symptoms associated with cognitive dysfunction which is estimated to transform into dementia in 50% cases.
Study design
The prospective randomised double-blind sham-controlled study aimed to determine the efficacy of WBC on cognitive functioning and biological mechanisms. The study was registered with Australian New Zealand Clinical Trials Registry (ACTRN12619001627145).
Methods
Participants with MCI (n = 62; (2026) were randomly allocated to cryogenic temperatures (-110 °C till -160 °C) (EG, n = 33) or placebo-controlled group (CG, n = 29). Cognitive functions were measured at baseline (T1), after the 10th WBC session (T2) and after 2 week-break (T3) with DemTect, SLUMS and Test Your Memory (TYM). Secondary outcome measures included quality of life (WHOQoL-BREF), self-reported well-being (VAS) and depressive symptoms (GDS). Whole blood samples (10 ml) were collected at T1 and T2 to evaluate levels of cytokines, neurotrophins, NO and biochemical parameters CRP total cholesterol, prolactin).
Results
There were significant differences between groups measured at T2 in immediate recall (DemTect) and in orientation (TYM) in favour of WBC group. Improvement in mood was detected in self-reported depressive symptoms level (WHOQoL-26; T2 p = 0.04; VAS mood T2 p = 0.02; T3 p = 0.07). The significant reduction of BDNF level was observed (p < 0.05).
Conclusions
WBC may increase the performance of cognitive functions. It seems promising to combine WBC with existing behavioural and cognitive trainings in the future studies investigating early interventions methods in MCI.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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