Financiado en parte por California Walnut Commission, California Walnuts Commission
Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial
Yaskolka Meir A, Rinott E, Tsaban G, Zelicha H, Kaplan A, Rosen P, Shelef I, Youngster I, Shalev A, Blüher M, Ceglarek U, Stumvoll M, Tuohy K, Diotallevi C, Vrhovsek U, Hu F, Stampfer M, Shai I
Gut · 210 citas
Etiquetas de revisión
Vínculos de autores con la industriaFinanciado por la industriaMezcla carne procesada con no procesadaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- Joint Programming Initiative A healthy diet for a healthy life
- Grupo de la industria
- California Walnut Commission
- Gobierno
- European Commission
- Gobierno
- Deutsche Forschungsgemeinschaft
- Universidad u hospital
- Ben-Gurion University of the Negev
- Gobierno
- ERA-Net Cofund ERA-HDHL “Biomarkers for Nutrition and Health implementing the JPI HDHL objectives”
- Gobierno
- European Union’s Horizon2020 research and innovation
- Gobierno
- Israel Ministry of Science and Technology
- Gobierno
- the Deutsche Forschungsgemeinschaft
- Grupo de la industria
- California Walnuts Commission
- Gobierno
- Israel Ministry of Health
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- Deutsche Forschungsgemeinschaft (SFB 1052); Deutsche Forschungsgemeinschaft (209933838); California Walnut Commission (87472511); European Commission (696295); Deutsche Forschungsgemeinschaft (SFB-1052/B11); California Walnut Commission (209933838); Deutsche Forschungsgemeinschaft (grant SFB1052); California Walnut Commission (SFB-1052/B11); Deutsche Forschungsgemeinschaft (87472511); Joint Programming Initiative A healthy diet for a healthy life (696295); California Walnut Commission (3-13604); Deutsche Forschungsgemeinschaft (3-13604); California Walnut Commission (SFB1052); European Commission (209933838)
Según 11 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-01-18 · Gut · vol. 70 · número 11 · págs. 2085–2095
- Editorial
- BMJ
- Citado
- 285 citas · más que el 100% de estudios similares · 26.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Agriculture Sustainability and Environmental Impact · Nutritional Studies and Diet · Animal Nutrition and Physiology
- Palabras clave
- Fatty liver, Weight loss, Medicine, Animal science, Obesity, Internal medicine, Polyphenol, Body mass index, Gastroenterology, Surgery, Biology, Disease, Biochemistry, Antioxidant
- MeSH
- humans, araceae, diet, reducing, diet, mediterranean, tea, middle aged, female, male, polyphenols, non-alcoholic fatty liver disease
18 autores
- Anat Yaskolka Meir🇮🇱Ben-Gurion University of the Negev
- Ehud Rinott🇮🇱Ben-Gurion University of the Negev
- Gal Tsaban🇮🇱Ben-Gurion University of the Negev; Soroka Medical Center
- Hila Zelicha🇮🇱Ben-Gurion University of the Negev
- Alon Kaplan🇮🇱Ben-Gurion University of the Negev
- Philip Rosen🇮🇱Soroka Medical Center
- Ilan Shelef🇮🇱Soroka Medical Center
- Ilan Youngster
- Aryeh Shaleṿ🇮🇱Soroka Medical Center
- Matthias Blüher🇩🇪University Hospital Leipzig; Leipzig University
- Uta Ceglarek🇩🇪Leipzig University
- Michael Stümvoll🇩🇪University Hospital Leipzig; Leipzig University
- Kieran Michael Tuohy🇮🇹Fondazione Edmund Mach
- Camilla Diotallevi🇮🇹Fondazione Edmund Mach; Free University of Bozen-Bolzano
- Urška Vrhovšek🇮🇹Free University of Bozen-Bolzano
- Frank B. Hu🇺🇸Brigham and Women's Hospital; Harvard University
- Meir J. Stampfer🇺🇸Brigham and Women's Hospital; Harvard University
- Iris Shai🇮🇱🇺🇸 · autor de correspondenciaBen-Gurion University of the Negev; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine the effectiveness of green-Mediterranean (MED) diet, further restricted in red/processed meat, and enriched with green plants and polyphenols on non-alcoholic fatty liver disease (NAFLD), reflected by intrahepatic fat (IHF) loss.
Design
For the DIRECT-PLUS 18-month randomized clinical trial, we assigned 294 participants with abdominal obesity/dyslipidaemia into healthy dietary guidelines (HDG), MED and green-MED weight-loss diet groups, all accompanied by physical activity. Both isocaloric MED groups consumed 28 g/day walnuts (+440 mg/day polyphenols provided). The green-MED group further consumed green tea (3-4 cups/day) and Mankai (a Wolffia globosa aquatic plant strain; 100 g/day frozen cubes) green shake (+1240 mg/day total polyphenols provided). IHF% 18-month changes were quantified continuously by proton magnetic resonance spectroscopy (MRS).
Results
Participants (age=51 years; 88% men; body mass index=31.3 kg/m2; median IHF%=6.6%; mean=10.2%; 62% with NAFLD) had 89.8% 18-month retention-rate, and 78% had eligible follow-up MRS. Overall, NAFLD prevalence declined to: 54.8% (HDG), 47.9% (MED) and 31.5% (green-MED), p=0.012 between groups. Despite similar moderate weight-loss in both MED groups, green-MED group achieved almost double IHF% loss (-38.9% proportionally), as compared with MED (-19.6% proportionally; p=0.035 weight loss adjusted) and HDG (-12.2% proportionally; pNaringenin and 2-5-dihydroxybenzoic-acid in green-MED. Greater IHF% loss was independently associated with increased Mankai and walnuts intake, decreased red/processed meat consumption, improved serum folate and adipokines/lipids biomarkers, changes in microbiome composition (beta-diversity) and specific bacteria (p<0.05 for all).
Conclusion
The new suggested strategy of green-Mediterranean diet, amplified with green plant-based proteins/polyphenols as Mankai, green tea, and walnuts, and restricted in red/processed meat can double IHF loss than other healthy nutritional strategies and reduce NAFLD in half.
Trial registration number
NCT03020186.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.