No evidence for brown adipose tissue activation after creatine supplementation in adult vegetarians
Connell NJ, Doligkeit D, Andriessen C, Kornips-Moonen E, Bruls YMH, Schrauwen-Hinderling VB, van de Weijer T, van Marken-Lichtenbelt WD, Havekes B, Kazak L, Spiegelman BM, Hoeks J, Schrauwen P
Nature metabolism · 19 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-01-18 · Nat Metab · vol. 3 · número 1 · págs. 107–117
- Editorial
- Nature Portfolio
- Citado
- 22 citas · más que el 86% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- De pago
- Áreas de investigación
- Adipose Tissue and Metabolism · Muscle metabolism and nutrition · Regulation of Appetite and Obesity
- Palabras clave
- brown adipose tissue, creatine supplementation, creatine monohydrate, thermogenesis, vegetarian diet, acute cold exposure, energy balance
- MeSH
- mitochondria, muscle, humans, creatine, fluorodeoxyglucose f18, radiopharmaceuticals, positron-emission tomography, body mass index, cross-over studies, double-blind method, body composition, dietary supplements, adolescent, adult, female, male, adipose tissue, brown, cold temperature, young adult, vegetarians
13 autores
- Niels J. Connell🇳🇱Maastricht University
- Daniel Doligkeit🇳🇱Maastricht University
- Charlotte Andriessen🇳🇱Maastricht University
- Esther Moonen‐Kornips🇳🇱Maastricht University
- Yvonne M. H. Bruls🇳🇱Maastricht University Medical Centre; Maastricht University
- Vera B. Schrauwen‐Hinderling🇳🇱Maastricht University Medical Centre; Maastricht University
- Tineke van de Weijer🇳🇱Maastricht University Medical Centre; Maastricht University
- Wouter D. van Marken Lichtenbelt🇳🇱Maastricht University
- Bas Havekes🇳🇱Maastricht University Medical Centre; Maastricht University
- Lawrence Kazak🇨🇦McGill University
- Bruce M. Spiegelman🇺🇸Harvard University; Dana-Farber Cancer Institute
- Joris Hoeks J🇳🇱Maastricht University
- Patrick Schrauwen🇳🇱 · autor de correspondenciaMaastricht University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Creatine availability in adipose tissue has been shown to have profound effects on thermogenesis and energy balance in mice. However, whether dietary creatine supplementation affects brown adipose tissue (BAT) activation in humans is unclear. In the present study, we report the results of a double-blind, randomized, placebo-controlled, cross-over trial (NCT04086381) in which 14 young, healthy, vegetarian adults, who are characterized by low creatine levels, received 20 g of creatine monohydrate per day or placebo. Participants were eligible if they met the following criteria: male or female, white, aged 18-30 years, consuming a vegetarian diet (≥6 months) and body mass index 20-25 kg m-2. BAT activation after acute cold exposure was determined by calculating standard uptake values (SUVs) acquired by [18F]fluorodeoxyglucose positron emission tomography-magnetic resonance imaging. BAT volume (-31.32 (19.32) SUV (95% confidence interval (CI) -73.06, 10.42; P = 0.129)), SUVmean (-0.34 (0.29) SUV (95% CI -0.97, 0.28; P = 0.254)) and SUVmax (-2.49 (2.64) SUV (95% CI -8.20, 3.21; P = 0.362)) following acute cold exposure were similar between placebo and creatine supplementation. No side effects of creatine supplementation were reported; one participant experienced bowel complaints during placebo, which resolved without intervention. Our data show that creatine monohydrate supplementation in young, healthy, lean, vegetarian adults does not enhance BAT activation after acute cold exposure.
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