Investigation on the biological activity of anthocyanins and polyphenols in blueberry
Yang S, Wang C, Li X, Wu C, Liu C, Xue Z, Kou X
Journal of food science · 37 citas
Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- National Key Research and Development Program of China
- Universidad u hospital
- Innovation Team of Tianjin Forestry & Pomology Research System
- Gobierno
- National Key R&D Program of China
- Subvenciones
- National Natural Science Foundation of China (31871848); National Key Research and Development Program of China (2019YFD1002300); National Natural Science Foundation of China (31671899)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2021-01-18 · J Food Sci · vol. 86 · número 2 · págs. 614–627
- Editorial
- Wiley
- Citado
- 64 citas · más que el 92% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 62 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Antioxidant Activity and Oxidative Stress · Bioactive natural compounds
- Palabras clave
- Polyphenol, Chemistry, Vaccinium, Antioxidant, Bilberry, Anthocyanin, Food science, Immune system, Biochemistry, Biological activity, Nitric oxide, Traditional medicine, In vitro, Botany, Biology, Immunology, Medicine
- MeSH
- humans, fruit, anthocyanins, plant extracts, antioxidants, polyphenols, blueberry plants
7 autores
- Sen Yeu Yang🇨🇳Tianjin University
- Chao Wang🇨🇳Tianjin University
- Xingyuan Li🇨🇳Tianjin University
- Caie Wu🇨🇳Nanjing Forestry University
- Chen Liu🇨🇳Tianjin University
- Zhaohui Xue🇨🇳 · autor de correspondenciaTianjin University
- Xiaohong Kou🇨🇳 · autor de correspondenciaTianjin University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Blueberry (Vaccinium spp.) is a fruit recognized in the world as healthy, and many of its active ingredients have important physiological functions. This study analyzed the antioxidant activity, antitumor activity, and immune function of anthocyanins and polyphenols extracted from blueberries. The crude extracts of anthocyanins and polyphenols were obtained from blueberries and then purified, and the extract exhibited excellent dose-dependent antitumor activity and antioxidant activity in vivo and in vitro. The purified anthocyanins and polyphenol compounds showed higher antioxidant activity, whereas the crude extract had a better inhibitory effect on tumor proliferation than pure extract, and the blueberry anthocyanin and polyphenol crude product mixture showed a more powerful tumor suppressor, which may be the result of the synergistic effect of multiple compounds. The crude extracts were also more efficient at improving immune function, as reflected by measurements of change in body weight, thymus and spleen indices, macrophage phagocytosis, lymphocyte transformation capacity, superoxide dismutase activity, malondialdehyde content, and serum nitric oxide levels. These results indicate that blueberry anthocyanins and polyphenol extracts can improve immune function and reduce the metastasis and proliferation of cancer cells. This study reveals the functions of important active substances in blueberries and provides support for the development of functional health products and therapeutic drugs. PRACTICAL APPLICATION: We compared the biological activity of crude and purified anthocyanins and polyphenol extracts from blueberries and tested their effects on improving immune function. This study contributes to a better understanding of the bioactivity of blueberry extracts and is valuable for further applications of blueberries in medicine.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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