A positive effect of egg consumption on macular pigment and healthy vision: a systematic review and meta-analysis of clinical trials
Khalighi Sikaroudi M, Saraf-Bank S, Clayton ZS, Soltani S
Journal of the science of food and agriculture · 12 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-01-24 · J Sci Food Agric · vol. 101 · número 10 · págs. 4003–4009
- Editorial
- Wiley
- Citado
- 14 citas · más que el 55% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- De pago
- Áreas de investigación
- Antioxidant Activity and Oxidative Stress · Retinal Diseases and Treatments · Retinoids in leukemia and cellular processes
- Palabras clave
- Lutein, Zeaxanthin, Macular degeneration, Meta-analysis, Medicine, Clinical trial, Ophthalmology, Randomized controlled trial, Internal medicine, Optical density, Subgroup analysis, Carotenoid, Food science, Biology
- MeSH
- animals, chickens, humans, lutein, eggs, adult, aged, middle aged, female, male, randomized controlled trials as topic, vision, ocular, zeaxanthins, macular pigment
4 autores
- Masoumeh Khalighi Sikaroudi🇮🇷Iran University of Medical Sciences
- Sahar Saraf‐Bank🇮🇷Isfahan University of Medical Sciences
- Zachary Stephen Clayton🇺🇸University of Colorado Boulder
- Sepideh Soltani🇮🇷 · autor de correspondenciaShahid Sadoughi University of Medical Sciences and Health Services
Resumen
El texto original del estudio, en el idioma en que se publicó.
Increasing macular pigment optical density (MPOD) as a result of increased macular concentration of lutein and zeaxanthin may reduce the risk of age-related macular degeneration (AMD). The aim of the present study was to determine whether the consumption of eggs, a rich source of dietary lutein and zeaxanthin, influences MPOD and serum lutein. In this systematic review and meta-analysis we searched PubMed, Scopus, and ISI Web of Science up to July 2020, for relevant randomized clinical trials. Using a random-effects model, pooled weighted mean differences, and standard deviations (SDs) for each outcome were obtained. The quality of the eligible studies was assessed by the Cochrane Collaboration's tool. A meta-analysis of five trials (296 participants) revealed that egg consumption significantly increased MPOD (weighted mean differences (WMD): +0.037; 95% CI: 0.004, 0.069; P = 0.027) and serum lutein (WMD: +0.150 μmol L̂-1; 95% CI: 0.037, 0.263; P = 0.009). Subgroup analyses showed that egg consumption: (a) had a larger effect on MPOD in studies with a parallel design; and (b) increased serum lutein to a greater extent in a healthy population. We did not detect any heterogeneity between studies. Daily egg consumption has beneficial effects on MPOD and serum lutein is inversely associated with reduced AMD progression. Further clinical trials are required to confirm the results of this study. © 2021 Society of Chemical Industry.
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