Effects of Vitamin D Supplementation on Prevention of Type 2 Diabetes in Patients With Prediabetes: A Systematic Review and Meta-analysis
Zhang Y, Tan H, Tang J, Li J, Chong W, Hai Y, Feng Y, Lunsford LD, Xu P, Jia D, Fang F
Diabetes care · 155 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-06-11 · Diabetes Care · vol. 43 · número 7 · págs. 1650–1658
- Editorial
- American Diabetes Association
- Citado
- 195 citas · más que el 98% de estudios similares · 6.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Diabetes Treatment and Management · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- vitamin D supplementation, type 2 diabetes prevention, prediabetes, obesity, vitamin D insufficiency
- MeSH
- humans, diabetes mellitus, type 2, prediabetic state, vitamin d, dietary supplements, adolescent, adult, aged, aged, 80 and over, middle aged, female, male, controlled clinical trials as topic, young adult
11 autores
- Yu Zhang🇨🇳Sichuan University; West China Hospital of Sichuan University; Chengdu University
- Huiwen Tan🇨🇳Sichuan University; West China Hospital of Sichuan University
- Jingjing Tang🇨🇳Chinese University of Hong Kong, Shenzhen
- Jing Li🇨🇳Sichuan University; West China Hospital of Sichuan University
- Weelic Chong🇺🇸Thomas Jefferson University
- Yang Hai🇺🇸Thomas Jefferson University
- Yuning Feng🇨🇳Chengdu University
- L. Dade Lunsford🇺🇸University of Pittsburgh; University of Pittsburgh Medical Center
- Ping Xu🇨🇳Sichuan University
- Desheng Jia🇨🇳Sichuan University; West China Hospital of Sichuan University
- Fang Fang🇨🇳 · autor de correspondenciaSichuan University; West China Hospital of Sichuan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
While observational studies have shown an association between vitamin D insufficiency and diabetes, it is unclear whether intervention with vitamin D supplements can lower the risk of type 2 diabetes mellitus (T2DM).
Purpose
To assess whether vitamin D supplementation reduces the risk of T2DM in people with prediabetes.
Data sources
We searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to 5 July 2019.
Study selection
We included randomized controlled trials assessing vitamin D supplementation versus placebo in relation to new-onset T2DM in people with prediabetes.
Data extraction
We screened studies and extracted data from published trials independently.
Data synthesis
We identified eight eligible trials with a total of 4,896 subjects. Vitamin D supplementation significantly reduced the risk of T2DM (risk ratio [RR] 0.89 [95% CI 0.80-0.99]; I 2 = 0%). Benefit was found in nonobese subjects (RR 0.73 [95% CI 0.57-0.92]) but not in obese subjects (RR 0.95 [95% CI 0.84-1.08]) (P interaction = 0.048). The reversion of prediabetes to normoglycemia occurred in 116 of 548 (21.2%) participants in the vitamin D group and 75 of 532 (14.1%) in the control group. Vitamin D supplementation increased reversion rate of prediabetes to normoglycemia (RR 1.48 [95% CI 1.14-1.92]; I 2 = 0%.) LIMITATIONS: Definitions of prediabetes and new-onset diabetes in eligible studies were different, and long-term data on outcomes of T2DM prevention were lacking.
Conclusions
In persons with prediabetes, vitamin D supplementation reduces the risk of T2DM and increases the reversion rate of prediabetes to normoglycemia. The benefit of the prevention of T2DM could be limited to nonobese subjects. Individual participant data meta-analyses are needed to confirm these findings.
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