The FADS1 Genotype Modifies Metabolic Responses to the Linoleic Acid and Alpha-linolenic Acid Containing Plant Oils-Genotype Based Randomized Trial FADSDIET2
Lankinen MA, de Mello VD, Meuronen T, Sallinen T, Ågren J, Virtanen KA, Laakso M, Pihlajamäki J, Schwab U
Molecular nutrition & food research · 21 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Itä-Suomen Yliopisto
- Gobierno
- Academy of Finland
- Subvenciones
- Academy of Finland (321428); Academy of Finland (309311); Academy of Finland (MAL 309311)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2021-02-06 · Mol Nutr Food Res · vol. 65 · número 7 · pág. e2001004
- Editorial
- Wiley
- Citado
- 31 citas · más que el 93% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Nutrition, Genetics, and Disease · Lipid metabolism and biosynthesis
- Palabras clave
- gene-diet interaction, linoleic acid, alpha-linolenic acid, sunflower oil, Camelina sativa oil, arachidonic acid, disposition index, insulin resistance, low-grade inflammation, high-sensitivity C-reactive protein, omega-3 fatty acids
- MeSH
- humans, inflammation, fatty acid desaturases, blood glucose, fatty acids, omega-3, alpha-linolenic acid, linoleic acid, phospholipids, plant oils, genotype, polymorphism, single nucleotide, aged, middle aged, male, sunflower oil, delta-5 fatty acid desaturase
9 autores
- Maria Anneli Lankinen🇫🇮 · autor de correspondenciaUniversity of Eastern Finland
- Vanessa D. de Mello🇫🇮University of Eastern Finland
- Topi Meuronen🇫🇮University of Eastern Finland
- Taisa Sallinen🇫🇮University of Eastern Finland
- Jyrki Ågren🇫🇮University of Eastern Finland
- Kirsi A. Virtanen🇫🇮University of Eastern Finland; Kuopio University Hospital
- Markku Laakso🇫🇮University of Eastern Finland; Kuopio University Hospital
- Jussi Pihlajamäki🇫🇮University of Eastern Finland; Kuopio University Hospital
- Ursula Schwab🇫🇮University of Eastern Finland; Kuopio University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Scope
The article investigates the FADS1 rs174550 genotype interaction with dietary intakes of high linoleic acid (LA) and high alpha-linolenic acid (ALA) on the response of fatty acid composition of plasma phospholipids (PLs), and of markers of low-grade inflammation and glucose-insulin homeostasis.
Methods and results
One-hundred thirty homozygotes men for FADS1 rs174550 SNP (TT and CC genotypes) were randomized to an 8-week intervention with either LA- or ALA-enriched diet (13 E% PUFA). The source of LA and ALA are 30-50 mL of sunflower oil (SFO, 62-63% LA) and Camelina sativa oil (CSO, 30- are randomized to an 35% ALA), respectively. In the SFO arm, there is a significant genotype x diet interaction for the proportion of arachidonic acid in plasma phospholipids (p 30 ) (p = 0.039), and for serum high-sensitive c-reactive protein (hs-CRP, p = 0.029) after excluding the participants with hs-CRP concentration of >10 mg L-1 and users of statins or anti-inflammatory therapy. In the CSO arm, there are significant genotype x diet interactions for n-3 polyunsaturated fatty acids, but not for the clinical characteristics.
Conclusions
The FADS1 genotype modifies the response to high PUFA diets, especially to high-LA diet. These findings suggest that approaches considering FADS variation may be useful in personalized dietary counseling.
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