The effect of almond intake on lipid profile: a systematic review and meta-analysis of randomized controlled trials
Asbaghi O, Moodi V, Hadi A, Eslampour E, Shirinbakhshmasoleh M, Ghaedi E, Miraghajani M
Food & function · 24 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-01-01 · Food Funct · vol. 12 · número 5 · págs. 1882–1896
- Editorial
- Royal Society of Chemistry
- Citado
- 31 citas · más que el 75% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 67 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nuts composition and effects · Fatty Acid Research and Health · Nutritional Studies and Diet
- Palabras clave
- lipid profile, triglycerides, total cholesterol, low-density lipoprotein, high-density lipoprotein, serum lipids, dose-response relationship, dyslipidemia, dietary intervention
- MeSH
- humans, nuts, lipids, adult, aged, middle aged, female, male, randomized controlled trials as topic, prunus dulcis, diet, healthy
7 autores
- Omid Asbaghi🇮🇷Lorestan University of Medical Sciences
- Vihan Moodi🇮🇷Tehran University of Medical Sciences
- Amir Hadi🇮🇷Isfahan University of Medical Sciences
- Elham Eslampour🇮🇷Lorestan University of Medical Sciences
- Mina Shirinbakhshmasoleh🇮🇷Tehran University of Medical Sciences
- Ehsan Ghaedi🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
- Maryam Sadat Miraghajani🇬🇧🇮🇷 · autor de correspondenciaUniversity of Nottingham; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
A number of clinical trials have examined the effect of almond intake on lipid profile in recent years; however, the results remain equivocal. Therefore, the present study aims to summarize and quantitatively examine the available evidence on the effectiveness of almond intake on lipid parameters by employing a systematic review and meta-analytic approach. Online databases including PubMed, Scopus, Embase, and Cochrane Library were searched up to September 2020 for randomized controlled trials that examined the effect of almond intake on lipid profile in adults. Treatment effects were expressed as weighted mean difference (WMD) and the corresponding standard error (SE) in the concentrations of serum lipids. To estimate the overall effect of almond intake, we employed the random-effect model. In total, 27 studies with 36 effect sizes were included in our analysis (1154 cases and 904 control subjects). The meta-analysis revealed that almond intake significantly changed the concentrations of triglycerides (WMD = -6.68 mg dL-1; 95% CI: -11.62, -1.75, p = 0.008), total cholesterol (WMD = -4.92 mg dL-1; 95% CI: -7.81, -2.03, p = 0.001), and low-density lipoproteins (WMD = -5.65 mg dL-1; 95% CI: -8.75, -2.55, p < 0.001); however it did not have a significant effect on high-density lipoprotein (WMD = -0.21 mg dL-1; 95% CI: -1.26, 0.84, p = 0.697) levels. Meta-regression analysis indicated a linear relationship between the dose of almond and change in TG (P = 0.021). This meta-analysis concludes that almond intake can significantly reduce lipid parameters. To draw straightforward conclusions regarding generalized recommendations for almond intake for improving lipid profile, there is a need for more well-controlled trials exclusively targeting patients with dyslipidaemia.
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