A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults
Tiwari S, Gupta SK, Pathak AK
Journal of ethnopharmacology · 32 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-02-16 · J Ethnopharmacol · vol. 272 · pág. 113929
- Editorial
- Elsevier BV
- Citado
- 59 citas · más que el 97% de estudios similares · 7.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 62 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Mindfulness and Compassion Interventions · Medicinal Plants and Bioactive Compounds
- Palabras clave
- Withania somnifera, Cardiorespiratory fitness, Traditional medicine, Placebo, Medicine, Phytotherapy, Randomized controlled trial, Physical therapy, Surgery, Alternative medicine
- MeSH
- humans, withania, plant roots, plant extracts, antioxidants, maximal voluntary ventilation, medicine, ayurvedic, prospective studies, double-blind method, sports, dietary supplements, adult, young adult, healthy volunteers, sports nutritional physiological phenomena, surveys and questionnaires, cardiorespiratory fitness
3 autores
- Shashank Tiwari · autor de correspondencia
- Sandeep Kumar Gupta🇮🇳M.V. Hospital and Research Centre
- Anklesh Kumar Pathak
Resumen
El texto original del estudio, en el idioma en que se publicó.
Ethnopharmacological relevance
Ashwagandha is a reputed herb in traditional Ayurveda, used for various ailments and improving general well-being. Improved cardiorespiratory endurance can aid in attaining better physiological, metabolic, and functional abilities in humans. According to Ayurveda, Ashwagandha has such potential to improve human health.
Aim of the study
This study aimed to evaluate the efficacy and safety of Ashwagandha root extract in enhancing cardiorespiratory endurance in healthy athletic adults.
Materials and methods
Fifty healthy athletic adults were selected randomly and equally allocated to Ashwagandha and placebo groups. The Ashwagandha group received 300 mg of Ashwagandha root extract capsules, twice daily, for 8-weeks. Cardiorespiratory endurance was assessed by measuring the maximum aerobic capacity (VO2 max). Estimation of stress management was done through Total Quality Recovery Scores (TQR), Recovery-Stress Questionnaire for Athletes (RESTQ), and Daily Analysis of Life Demands for Athletes (DALDA) questionnaires along with the antioxidant level measurement.
Results
At the end of the study, a statistically significant improvement in VO2 max outcome was observed in the Ashwagandha group when compared to the placebo group (P = 0.0074). The subjects in the Ashwagandha group also displayed a statistically significant increase at the end of the study when compared to the baseline (P < 0.0001). Significantly improved TQR scores were observed in the Ashwagandha group members compared to their placebo counterparts (P < 0.0001). DALDA questionnaire analysis in the Ashwagandha group was found statistically significant (P < 0.0001) compared to the placebo group. RESTQ assessment also yielded better outcomes, especially for fatigue recovery (P < 0.0001), lack of energy (P < 0.0001), and fitness analysis (P < 0.0001). The enhanced antioxidant level was significant (P < 0.0001) in the Ashwagandha group.
Conclusion
The present findings suggest that Ashwagandha root extract can successfully enhance cardiorespiratory endurance and improve the quality of life in healthy athletic adults. No adverse events were reported by any of the subjects in this study.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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