Contribution of ultra-processed foods in visceral fat deposition and other adiposity indicators: Prospective analysis nested in the PREDIMED-Plus trial
Konieczna J, Morey M, Abete I, Bes-Rastrollo M, Ruiz-Canela M, Vioque J, Gonzalez-Palacios S, Daimiel L, Salas-Salvadó J, Fiol M, Martín V, Estruch R, Vidal J, Martínez-González MA, Canudas S, Jover AJ, Fernández-Villa T, Casas R, Olbeyra R, Buil-Cosiales P, Babio N, Schröder H, Martínez JA, Romaguera D, PREDIMED-Plus investigators
Clinical nutrition (Edinburgh, Scotland) · 64 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- European Research Council
Según 1 financiador declarado.
Publicación
- Publicado
- 2021-01-27 · Clin Nutr · vol. 40 · número 6 · págs. 4290–4300
- Editorial
- Elsevier BV
- Citado
- 81 citas · más que el 99% de estudios similares · 11.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 59 trabajos
- Acceso
- De pago
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Obesity, Physical Activity, Diet
- Palabras clave
- ultra-processed foods, visceral fat, adiposity, android/gynoid fat ratio, fat mass, NOVA classification, food processing degree, obesity, metabolic syndrome, PREDIMED-Plus trial, body composition, dietary intake, aging, older adults, dietary change over time, Mediterranean diet, weight loss maintenance
- MeSH
- humans, obesity, absorptiometry, photon, diet, diet surveys, longitudinal studies, prospective studies, aged, middle aged, spain, female, male, intra-abdominal fat, adiposity, overweight, fast foods, metabolic syndrome
24 autores
- Jadwiga Konieczna🇪🇸 · autor de correspondenciaInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Centro de Investigación Biomédica en Red; Health Research Institute of the Balearic Islands; Hospital Universitario Son Espases
- Marga Morey🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Centro de Investigación Biomédica en Red; Health Research Institute of the Balearic Islands; Hospital Universitario Son Espases
- Itziar Abete🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Centro de Investigación Biomédica en Red; Universidad de Navarra
- Maira Bes‐Rastrollo🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Centro de Investigación Biomédica en Red; Universidad de Navarra
- Miguel Ruiz‐Canela🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Centro de Investigación Biomédica en Red; Universidad de Navarra
- Jesús Vioqué🇪🇸Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL)
- Sandra González‐Palacios🇪🇸Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL)
- Lidia Daimiel🇪🇸Madrid Institute for Advanced Studies; IMDEA Food
- Jordi Salas‐Salvadó🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Institut de Recerca Biomèdica Catalunya Sud; Centro de Investigación Biomédica en Red; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
- Miquel Fiol🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Centro de Investigación Biomédica en Red; Health Research Institute of the Balearic Islands; Hospital Universitario Son Espases
- Vicente Martín🇪🇸Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Universidad de León
- Ramón Estruch🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Centro de Investigación Biomédica en Red; Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer; Universitat de Barcelona
- Josép Vidal🇪🇸Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer; Universitat de Barcelona
- Miguel Ángel Martínez‐González🇺🇸🇪🇸Harvard University; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Centro de Investigación Biomédica en Red; Universidad de Navarra
- Sı́lvia Canudas🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Institut de Recerca Biomèdica Catalunya Sud; Centro de Investigación Biomédica en Red; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
- Antonio Jover Palmer🇪🇸Servei de Salut de les Illes Balears
- Tania Fernández-Villa🇪🇸Universidad de León
- Rosa Mª Casas🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Centro de Investigación Biomédica en Red; Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer; Universitat de Barcelona
- Romina Paula Olbeyra🇪🇸Consorci Institut D'Investigacions Biomediques August Pi I Sunyer; Universitat de Barcelona
- Pilar Buil‐Cosiales🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Servicio Navarro de Salud; Navarre Institute of Health Research; Centro de Investigación Biomédica en Red; Universidad de Navarra
- Nancy Babió🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Institut de Recerca Biomèdica Catalunya Sud; Centro de Investigación Biomédica en Red; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
- Helmut Schröder🇪🇸Instituto de Salud Carlos III; Hospital Del Mar; Municipal Institute for Medical Research; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Hospital del Mar Research Institute
- José Alfredo Martínez🇪🇸Madrid Institute for Advanced Studies; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Centro de Investigación Biomédica en Red; IMDEA Food; Universidad de Navarra
- Dora Romaguera🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Centro de Investigación Biomédica en Red; Health Research Institute of the Balearic Islands; Hospital Universitario Son Espases
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Ultra-processed food and drink products (UPF) consumption has been associated with obesity and its-related comorbidities. Excess of visceral fat, which appears with increasing age, has been considered as the culprit contributing to adiposity-associated adverse health outcomes. However, none of previous studies elucidated the link between UPF and directly quantified adiposity and its distribution. We aimed to prospectively investigate the association between concurrent changes in UPF consumption and objectively assessed adiposity distribution.
Methods
A subsample of 1485 PREDIMED-Plus participants (Spanish men and women aged 55-75 years with overweight/obesity and metabolic syndrome) underwent body composition measurements. Consumption of UPF at baseline, 6 and 12 months was evaluated using a validated 143-item semi-quantitative Food Frequency Questionnaire. Food items (g/day) were categorized according to their degree of processing using NOVA system. Regional adiposity (visceral fat (in g) and android-to-gynoid fat ratio) and total fat mass (in g) at three time points were measured with dual-energy X-ray absorptiometry (DXA) and were normalized using sex-specific z-scores. The association of changes in UPF consumption, expressed as the percentage of total daily intake (daily g of UPF/total daily g of food and beverage intake∗100), with adiposity changes was evaluated using linear mixed-effects models.
Results
On average, the consumption of UPF accounted for 8.11% (SD 7.41%) of total daily intake (in grams) at baseline. In multivariable-adjusted model, 10% daily increment in consumption of UPF was associated with significantly (all p-values <0.05) greater accumulation of visceral fat (β 0.09 z-scores, 95% CI 0.05; 0.13), android-to-gynoid fat ratio (0.05, 0.00; 0.09) and total fat (0.09, 0.06; 0.13).
Conclusion
A higher consumption of UPF was associated with greater age-related visceral and overall adiposity accumulation. Further studies are warranted to confirm these results in other populations and settings.
Trial registration
The trial was registered at the International Standard Randomized Controlled Trial (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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