Effects of acute dietary nitrate supplementation on cold-induced vasodilation in healthy males
Wickham KA, Steele SW, Cheung SS
European journal of applied physiology · 11 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Natural Sciences and Engineering Research Council of Canada
- Gobierno
- Natural Sciences and Engineering Research Council of Canada (CA)
- Subvenciones
- Natural Sciences and Engineering Research Council of Canada (201804077)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2021-02-23 · Eur J Appl Physiol · vol. 121 · número 5 · págs. 1431–1439
- Editorial
- Springer Science+Business Media
- Citado
- 12 citas · más que el 74% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Thermoregulation and physiological responses · Nitric Oxide and Endothelin Effects · Cardiovascular and exercise physiology
- Palabras clave
- cold-induced vasodilation, dietary nitrate, beetroot juice, nitric oxide, skin blood flow, mean arterial pressure, cold water immersion, skin temperature, laser Doppler flowmetry, sympathetic withdrawal, healthy men
- MeSH
- fingers, humans, nitrates, laser-doppler flowmetry, cross-over studies, double-blind method, skin temperature, vasodilation, dietary supplements, male, cold temperature, young adult, healthy volunteers
3 autores
- Kate Aiko Wickham🇨🇦Brock University
- Scott W. Steele🇨🇦Brock University
- Stephen S. Cheung🇨🇦 · autor de correspondenciaBrock University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Cold-induced vasodilation (CIVD) is a paradoxical rise in blood flow to the digits that occur during prolonged cold exposure. CIVD is thought to occur through active vasodilation and/or sympathetic withdrawal, where nitric oxide (NO) may play a key role in mediating these mechanisms. Beetroot juice (BRJ) is high in dietary nitrate (NO3-) which undergoes sequential reduction to nitrite (NO2-) and subsequently NO. Using a double-blind, randomized, crossover design, we examined the effect of acute BRJ supplementation on the CIVD response in 10 healthy males.
Methods
Participants had a resting blood pressure measurement taken prior to ingesting 140 mL of nitrate-rich BRJ (13 mmol NO3-) or a NO3--free placebo (PLA). After 2 h, participants immersed their hand in neutral water (~ 35 °C) for 10 min of baseline before cold water immersion (~ 8 °C) for 30 min. Laser-Doppler fluxmetry and skin temperature were measured continuously on the digits.
Results
Compared to PLA (100 ± 3 mmHg), acute BRJ supplementation significantly reduced mean arterial pressure at -30 min (96 ± 2 mmHg; p = 0.007) and 0 min (94 ± 2 mmHg; p = 0.008). Acute BRJ supplementation had no effect on Laser-Doppler fluxmetry during CIVD (expressed as cutaneous vascular conductance) measured as area under the curve (BRJ: 843 ± 148 PU mmHg-1 s; PLA: 1086 ± 333 PU mmHg-1 s), amplitude (BRJ: 0.60 ± 0.12 PU mmHg-1; PLA: 0.69 ± 0.14 PU mmHg-1), and duration (BRJ: 895 ± 60 s; PLA: 894 ± 46 s).
Conclusion
Acute BRJ supplementation does not augment the CIVD response in healthy males.
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