The Effect of Creatine Supplementation on Markers of Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis of Human Intervention Trials
Northeast B, Clifford T
International journal of sport nutrition and exercise metabolism · 15 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-02-25 · Int J Sport Nutr Exerc Metab · vol. 31 · número 3 · págs. 276–291
- Editorial
- Human Kinetics
- Citado
- 27 citas · más que el 52% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 71 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Muscle metabolism and nutrition · Exercise and Physiological Responses · Sports Performance and Training
- Palabras clave
- creatine supplementation, exercise-induced muscle damage, muscle recovery, creatine kinase, muscle soreness, muscle strength, range of motion, inflammation, oxidative stress
- MeSH
- humans, myositis, creatine, l-lactate dehydrogenase, creatine kinase, muscle proteins, range of motion, articular, exercise, confidence intervals, chi-square distribution, recovery of function, oxidative stress, time factors, dietary supplements, publication bias, adult, middle aged, female, male, muscle strength, randomized controlled trials as topic, young adult, performance-enhancing substances, myalgia, biomarkers
2 autores
- Bethany Northeast🇬🇧Loughborough University
- Tom Clifford🇬🇧Loughborough University
Resumen
El texto original del estudio, en el idioma en que se publicó.
This systematic review and meta-analysis examined the effects of creatine supplementation on recovery from exercise-induced muscle damage, and is reported according to the PRISMA guidelines. MEDLINE and SPORTDiscus were searched for articles from inception until April 2020. Inclusion criteria were adult participants (≥18 years); creatine provided before and/or after exercise versus a noncreatine comparator; measurement of muscle function recovery, muscle soreness, inflammation, myocellular protein efflux, oxidative stress; range of motion; randomized controlled trials in humans. Thirteen studies (totaling 278 participants; 235 males and 43 females; age range 20-60 years) were deemed eligible for analysis. Data extraction was performed independently by both authors. The Cochrane Collaboration Risk of Bias Tool was used to critically appraise the studies; forest plots were generated with random-effects model and standardized mean differences. Creatine supplementation did not alter muscle strength, muscle soreness, range of motion, or inflammation at each of the five follow-up times after exercise ( .05). Creatine attenuated creatine kinase activity at 48-hr postexercise (standardized mean difference: -1.06; 95% confidence interval [-1.97, -0.14]; p = .02) but at no other time points. High (I2; >75%) and significant (Chi2; p < .01) heterogeneity was identified for all outcome measures at various follow-up times. In conclusion, creatine supplementation does not accelerate recovery following exercise-induced muscle damage; however, well-controlled studies with higher sample sizes are warranted to verify these conclusions. Systematic review registration (PROSPERO CRD42020178735).
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