Dietary Blueberry and Soluble Fiber Supplementation Reduces Risk of Gestational Diabetes in Women with Obesity in a Randomized Controlled Trial
Basu A, Feng D, Planinic P, Ebersole JL, Lyons TJ, Alexander JM
The Journal of nutrition · 65 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Nevada, Las Vegas
- Gobierno
- National Institute of General Medical Sciences
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NIGMS NIH HHS
- Subvenciones
- National Institute of General Medical Sciences (P20GM103440); National Institute of Diabetes and Digestive and Kidney Diseases (P30DK123704); National Institute of General Medical Sciences (GM103440)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2020-12-13 · J Nutr · vol. 151 · número 5 · págs. 1128–1138
- Editorial
- Elsevier BV
- Citado
- 90 citas · más que el 96% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 77 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Gestational Diabetes Research and Management · Natural Antidiabetic Agents Studies · Nutritional Studies and Diet
- Palabras clave
- gestational diabetes mellitus, maternal obesity, dietary polyphenols, cardiometabolic risk, gestational weight gain, C-reactive protein, blood glucose, lipid profile, early pregnancy, Hispanic women, dietary intervention, prenatal care, nutrition education, glucose challenge test, dietary adherence, insulin resistance, maternal morbidity
- MeSH
- humans, diabetes, gestational, inflammation, insulin, blood glucose, lipids, diet, pregnancy, dietary fiber, adult, female, prenatal nutritional physiological phenomena, young adult, biomarkers, blueberry plants, glycated hemoglobin, pregnancy in obesity
6 autores
- Arpita Basu🇺🇸 · autor de correspondenciaUniversity of Nevada, Las Vegas
- Feng Du🇺🇸University of Nevada, Las Vegas
- Petar Planinić🇺🇸University of Nevada, Las Vegas
- Jeffrey L. Ebersole🇺🇸University of Nevada, Las Vegas
- Timothy J. Lyons🇺🇸Medical University of South Carolina
- James M. Alexander🇺🇸University of Nevada, Las Vegas
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Gestational diabetes mellitus (GDM) is a growing public health concern and maternal obesity and poor dietary intakes could be implicated. Dietary polyphenols and fiber mitigate the risk of diabetes and its complications, but little is known about their efficacy in preventing GDM.
Objectives
We examined the effects of whole blueberry and soluble fiber supplementation on primary outcomes of cardiometabolic profiles in women at high risk of developing GDM.
Methods
Women (n = 34; mean ± SD age: 27 ± 5 y; BMI: 35.5 ± 4.0 kg/m2; previous history of GDM ∼56%; Hispanic ∼79%) were recruited in early pregnancy (<20 weeks of gestation) and randomly assigned to 1 of the following 2 groups for 18 wk: intervention (280 g whole blueberries and 12 g soluble fiber per day) and standard prenatal care (control). Both groups received nutrition education and maintained 24-h food recalls throughout the study. Data on anthropometrics, blood pressure, and blood samples for biochemical analyses were collected at baseline (<20 weeks), midpoint (24-28 weeks), and end (32-36 weeks) of gestation. Diagnosis of GDM was based on a 2-step glucose challenge test (GCT). Data were analyzed using a mixed-model ANOVA.
Results
Maternal weight gain was significantly lower in the dietary intervention than in the control group at the end of the trial (mean ± SD: 6.8 ± 3.2 kg compared with 12.0 ± 4.1 kg, P = 0.001). C-reactive protein was also lower in the intervention than in the control group (baseline: 6.1 ± 4.0 compared with 6.8 ± 7.2 mg/L; midpoint: 6.1 ± 3.7 compared with 7.5 ± 7.3 mg/L; end: 5.5 ± 2.2 compared with 9.5 ± 6.6 mg/L, respectively, P = 0.002). Blood glucose based on GCT was lower in the intervention than in the control (100 ± 33 mg/dL compared with 131 ± 40 mg/dL, P < 0.05). Conventional lipids (total, LDL, and HDL cholesterol and triglycerides) did not differ between groups over time. No differences were noted in infant birth weight.
Conclusions
Whole blueberry and soluble fiber supplementation may prevent excess gestational weight gain and improve glycemic control and inflammation in women with obesity.This trial was registered at clinicaltrials.gov as NCT03467503.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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