Magnesium intake, insulin resistance and markers of endothelial function among women
Bavani NG, Saneei P, Hassanzadeh Keshteli A, Yazdannik A, Falahi E, Sadeghi O, Esmaillzadeh A
Public health nutrition · 10 citas
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Isfahan University of Medical Sciences
- Universidad u hospital
- Lorestan University of Medical Sciences
- Universidad u hospital
- Food Security Research Center, Isfahan University of Medical Sciences
Según 3 financiadores declarados.
Publicación
- Publicado
- 2021-03-15 · Public Health Nutr · vol. 24 · número 17 · págs. 5777–5785
- Editorial
- Cambridge University Press
- Citado
- 14 citas · más que el 72% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Potassium and Related Disorders
- Palabras clave
- Insulin resistance, Insulin sensitivity, Magnesium, Function (biology), Insulin, Linkage (software)
- MeSH
- humans, insulin resistance, magnesium, insulin, blood glucose, cross-sectional studies, iran, female, biomarkers
7 autores
- Narges Ghorbani Bavani🇮🇷Isfahan University of Medical Sciences
- Parvane Saneei🇮🇷Isfahan University of Medical Sciences
- Ammar Hassanzadeh Keshteli🇨🇦University of Alberta
- Ahmadreza Yazdannik🇮🇷Isfahan University of Medical Sciences; Iranshahr University
- Ebrahim Falahi🇮🇷Lorestan University of Medical Sciences
- Omid Sadeghi🇮🇷Tehran University of Medical Sciences
- Ahmad Esmaillzadeh🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences; Obesity and Eating Habits Research Center; Tehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
We investigated the association of dietary Mg intake with insulin resistance and markers of endothelial function among Iranian women.
Design
A cross-sectional study.
Setting
Usual dietary intakes were assessed using a validated FFQ. Dietary Mg intake was calculated by summing up the amount of Mg in all foods. A fasting blood sample was taken to measure serum concentrations of glycemic indices (fasting plasma glucose and insulin) and endothelial function markers (E-selectin, soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1). Insulin resistance and sensitivity were estimated using the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), Homeostasis Model Assessment β-cell function (HOMA-β) and quantitative insulin sensitivity check index (QUICKI).
Participants
Iranian female nurses (n 345) selected by a multistage cluster random sampling method.
Results
The Mg intake across energy-adjusted quartiles was 205 (se 7), 221·4 (se 8), 254·3 (se 7) and 355·2 (se 9) mg/d, respectively. After adjustments for potential confounders, QUICKI level was significantly different across quartiles of Mg intake (Q1: 0·34 (se 0·02), Q2: 0·36 (se 0·01), Q3: 0·40 (se 0·01), and Q4: 0·39 (se 0·02), P = 0·02); however, this association disappeared after considering markers of endothelial function, indicating that this relation might be mediated through endothelial dysfunction. After controlling for all potential confounders, Mg intake was inversely, but not significantly, associated with serum concentrations of sICAM (Q1: 239 (se 17), Q2: 214 (se 12), Q3: 196 (se 12), and Q4: 195 (se 17), P = 0·29). There was no other significant association between dietary Mg intake and other indicators of glucose homoeostasis or endothelial markers.
Conclusions
Higher dietary Mg intake was associated with better insulin sensitivity in Iranian females. This linkage was mediated through reduced endothelial dysfunction.
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